000168565 001__ 168565 000168565 005__ 20260211123807.0 000168565 0247_ $$2doi$$a10.1364/BOE.579879 000168565 0248_ $$2sideral$$a148033 000168565 037__ $$aART-2026-148033 000168565 041__ $$aeng 000168565 100__ $$aMiazdzyk, Maria 000168565 245__ $$aEstimating the optical properties of corneal tissue from the OCT speckle 000168565 260__ $$c2026 000168565 5060_ $$aAccess copy available to the general public$$fUnrestricted 000168565 5203_ $$aEstimating the scattering coefficient µs and scattering anisotropy factor g of the corneal tissue is currently limited to methods utilizing double integrating spheres or spectroscopic techniques, prohibiting such corneal tissue evaluation from being performed in a clinical setting. This paper presents a new concept of statistical matching between a given corneal optical coherence tomography (OCT) scan and a set of multi-reference phantom OCT B-scans, suitably simulated using the Monte Carlo method. The statistical matching that exploits the information present in the speckle includes an ensemble of distance measures. Using a set of OCT scans from 11 porcine eyeballs, for which epithelium was removed, it is demonstrated that the proposed statistical matching approach leads to a precise estimation of the optical properties of corneal stroma. The group mean of the scattering coefficient and the scattering anisotropy factor for the porcine stroma were µ¯s = 0.146 ± 0.020 mm−1 and g¯ = 0.893 ± 0.021, respectively. These estimates match previously reported values established with other methods. The proposed approach of utilizing information present in the speckle can be readily extended to in vivo OCT imaging of human corneal tissue. 000168565 536__ $$9info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101162733/EU/Visual Impairment Screening using Images from Ophthalmology and Novel pathways for Structural Analysis and Fast Evaluation/VISIONSAFE 000168565 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000168565 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000168565 700__ $$0(orcid)0000-0001-5186-1837$$aConsejo, Alejandra$$uUniversidad de Zaragoza 000168565 700__ $$aIskander, D. Robert 000168565 7102_ $$12002$$2385$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Física Aplicada 000168565 773__ $$g17, 2 (2026), 544 [11 pp.]$$pBIOMEDICAL OPTICS EXPRESS$$tBiomedical Optics Express$$x2156-7085 000168565 8564_ $$s7413800$$uhttps://zaguan.unizar.es/record/168565/files/texto_completo.pdf$$yVersión publicada 000168565 8564_ $$s2388585$$uhttps://zaguan.unizar.es/record/168565/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000168565 909CO $$ooai:zaguan.unizar.es:168565$$particulos$$pdriver 000168565 951__ $$a2026-02-11-10:27:18 000168565 980__ $$aARTICLE