168574 20260211123813.0 doi 10.1016/j.jdin.2025.12.005 sideral 148022 ART-2025-148022 eng Balieva, Flora Stress in dermatology patients: A multicenter observational study of 8295 outpatients and controls from 22 European clinics 2025 Background Skin diseases are symptomatic, visible, and stigmatizing and it is acknowledged that they can be associated with stress. However, large studies comparing disease-specific stress are scarce. Objectives To investigate stress in a large, diverse sample of patients with different skin conditions and identify predictors of stress. Methods A cross-sectional, multicenter study was conducted in 22 dermatology clinics across 17 European countries (response rate 82.4%). The study included 5487 patients diagnosed with various dermatological conditions and 2808 skin-healthy controls. The Perceived Stress Scale, 10 items was used to measure stress. Results Patients reported significantly higher stress levels, more stressful life events during the last 6 months, and more economic difficulties than controls. Patients with psychodermatological conditions, hyperhidrosis, hidradenitis suppurativa, atopic dermatitis, acne, and urticaria experienced the highest stress levels. 44% of the variance of perceived stress in patients with skin conditions could be predicted by sociodemographic data and disease-related and psychological variables (depression, anxiety, stigmatization, and body dysmorphic concerns). Limitations As with all cross-sectional studies, causality and directionality cannot be inferred. Conclusion Stress poses a significant psychosocial burden to dermatological patients, especially to vulnerable subgroups. Health interventions targeting stress may be essential to improve clinical outcomes. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Schut, Christina Szabó, Csanád Sampogna, Francesca Dalgard, Florence J. Altunay, Ilknur K. Bewley, Anthony Ferreira, Bárbara Roque Finlay, Andrew Y. Gieler, Uwe Gracia-Cazaña, Tamara Universidad de Zaragoza Grivcheva-Panovska, Vesna Jemec, Gregor B. Legat, Franz J. Lien, Lars Lvov, Andrey Marron, Servando E. Universidad de Zaragoza (orcid)0000-0001-5632-0351 Misery, Laurent Reich, Adam Romanov, Dmitry Koulil, Saskia Spillekom-van Ständer, Sonja Svensson, Ake Szepietowski, Jacek C. Thompson, Andrew R. Titeca, Geraldine Tomás-Aragonés, Lucía (orcid)0000-0003-1917-6906 Vulink, Nienke Zeidler, Claudia Kupfer, Jörg 1007 183 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Área Dermatología 25, 69-77 (2025), [9 pp.] JAAD International 2666-3287 1902277 http://zaguan.unizar.es/record/168574/files/texto_completo.pdf Versión publicada 2399892 http://zaguan.unizar.es/record/168574/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:168574 articulos driver 2026-02-11-10:27:29 ARTICLE