000168587 001__ 168587 000168587 005__ 20260211123813.0 000168587 0247_ $$2doi$$a10.1016/j.jad.2025.120847 000168587 0248_ $$2sideral$$a147997 000168587 037__ $$aART-2025-147997 000168587 041__ $$aeng 000168587 100__ $$aAlonso, Jordi 000168587 245__ $$aMental disorders & self-injurious thoughts and behaviors predict high risk of role impairment among university students - results from the world mental health international college student initiative 000168587 260__ $$c2025 000168587 5203_ $$aObjective We examined psychopathological conditions accounting for the highest risk of role impairment among university students. Method Cross-sectional online survey of first-year students (60 universities, 10 countries) assessing role impairment due to emotional problems in previous 30 days with the 3-item emotional subscale of the VR-36. Cross-tabulations and Poisson regression examined associations between 12 psychopathological conditions (8 probable mental disorders and 4 SITB) and socio-demographics with “significant role impairment” (“most”/”all of the time” in 2+ VR-36 items). We used machine learning methods to predict probabilities (risk) of significant role impairment based on the 12 psychopathological conditions. Observed prevalence of significant role impairment was examined within and across the 20 population ventiles to assess risk concentration using sensitivity (SN) and positive predictive value (PPV). Results 43,990 students responded to the survey (median age = 19, IQR = 18–23). 27.1 % had significant role impairment due to emotional problems and 65.8 % had at least one psychopathological condition. Students with one or more of these conditions were more likely to have significant impairment than those without (RR = 3.9; 95 %CI: 3.6–4.2). In multivariable analyses, probable Depression and Bipolar disorders were the strongest correlates of significant impairment. Most (69.6 %) of the observed significant role impairment occurred among the roughly 35 % of respondents with highest predicted risk (PPV = 53.2 %). Conclusion Significant role impairment due to emotional problems is highly prevalent among university students. High risk of significant role impairment concentrates in one third of the students, those with several psychopathological conditions. Assessing these conditions should help identifying highest role impairment risk university students. 000168587 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CB06-02-0046$$9info:eu-repo/grantAgreement/ES/ISCIII/CD23-00010$$9info:eu-repo/grantAgreement/ES/ISCIII/PI20-00006 000168587 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000168587 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000168587 700__ $$aPetukhova, Maria V. 000168587 700__ $$aLee, Sue 000168587 700__ $$aSampson, Nancy A. 000168587 700__ $$aAltwaijri, Yasmin A. 000168587 700__ $$aAlHadi, Ahmad N. 000168587 700__ $$aAl-Saud, Nouf K. 000168587 700__ $$aAndersson, Claes 000168587 700__ $$aAuerbach, Randy P. 000168587 700__ $$aBallester, Laura 000168587 700__ $$aBantjes, Jason 000168587 700__ $$aBendtsen, Marcus 000168587 700__ $$aBenjet, Corina 000168587 700__ $$aBerman, Anne H. 000168587 700__ $$aCarrasco, Paula 000168587 700__ $$aChan, Silver C.N. 000168587 700__ $$aCohut, Irina 000168587 700__ $$aCrockett, Marcelo A. 000168587 700__ $$aCuijpers, Pim 000168587 700__ $$aDavid, Oana A. 000168587 700__ $$aDong, Dong 000168587 700__ $$aGaete, Jorge 000168587 700__ $$aFelez-Nobrega, Mireia 000168587 700__ $$aGarcía Forero, Carlos 000168587 700__ $$aGili, Margalida 000168587 700__ $$aGutiérrez-García, Raúl A. 000168587 700__ $$aHaro, Josep Maria 000168587 700__ $$aHunt, Xanthe 000168587 700__ $$aLanger, Álvaro I. 000168587 700__ $$aLéniz, Irene 000168587 700__ $$aLiu, Yan 000168587 700__ $$aMac-Ginty, Scarlett 000168587 700__ $$aMartínez, Vania 000168587 700__ $$aMason, Andre 000168587 700__ $$aMiranda-Mendizábal, Andrea 000168587 700__ $$aNúñez, Daniel 000168587 700__ $$aPapasteri, Claudiu C. 000168587 700__ $$aPiqueras, José A. 000168587 700__ $$aPopescu, Codruta A. 000168587 700__ $$aRapsey, Charlene 000168587 700__ $$aRodríguez-Jiménez, Tiscar$$uUniversidad de Zaragoza 000168587 700__ $$aSaal, Wylene 000168587 700__ $$aSiu, Oi-ling 000168587 700__ $$aStein, Dan J. 000168587 700__ $$aStruijs, Sascha Y. 000168587 700__ $$aT.Tomoiaga, Cristina 000168587 700__ $$aWong, Samuel Y.S. 000168587 700__ $$aVilagut, Gemma 000168587 700__ $$aKessler, Ronald C. 000168587 7102_ $$14009$$2680$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Person.Eval.Trat.Psicoló. 000168587 773__ $$g397 (2025), 120847 [11 pp.]$$pJ. affect. disord.$$tJournal of Affective Disorders$$x0165-0327 000168587 8564_ $$s808700$$uhttps://zaguan.unizar.es/record/168587/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-12-15 000168587 8564_ $$s2536116$$uhttps://zaguan.unizar.es/record/168587/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-12-15 000168587 909CO $$ooai:zaguan.unizar.es:168587$$particulos$$pdriver 000168587 951__ $$a2026-02-11-10:27:46 000168587 980__ $$aARTICLE