000168627 001__ 168627
000168627 005__ 20260212205631.0
000168627 0247_ $$2doi$$a10.1016/j.indcrop.2025.122479
000168627 0248_ $$2sideral$$a148054
000168627 037__ $$aART-2026-148054
000168627 041__ $$aeng
000168627 100__ $$aCebollada, Pilar
000168627 245__ $$aAntibacterial and anti-biofilm properties of Cymbopogon martini (Roxb.) essential oil and geraniol against Staphylococcus aureus strains
000168627 260__ $$c2026
000168627 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168627 5203_ $$aCymbopogon martini (Roxb.) Wats, known as palmarosa, a perennial aromatic grass cultivated for its essential oil, represents a promising industrial crop widely used in perfumery, cosmetics, self-care products, and aromatherapy, with emerging applications in pharmaceutical formulations. This study investigates the chemical composition and antimicrobial potential of Cymbopogon martini essential oil and one of its main components, geraniol, against Staphylococcus aureus from clinical isolates and commercial sources. The effect upon planktonic state was assessed obtaining the MIC and MBC values. Biofilm viability and biomass were quantified using resazurin and crystal violet assays, respectively. Additionally, membrane disruption was explored as a potential mechanism of action. Potential toxicity was evaluated in A549 and HaCaT cell lines and in adult Artemia spp. GC-MS analysis revealed the presence of geraniol as the major compound (75.29 %) but also other terpenes like geranyl acetate (10.39 %), (E)-β-caryophyllene (3.14 %), linalool (2.90 %) and trans-β-ocimene (1.36 %). The essential oil displayed lower MIC and MBC values (MIC: 300–350 µg ml−1; MBC: 400 µg ml−1-450 µg ml−1) than the pure geraniol (MIC: 500 µg ml−1; MBC: 550–600 µg ml−1). Results showed nearly 100 % inhibition of biofilm formation across tested concentrations (500 µg ml−1 to 1000 µg ml−1). Unlike vancomycin, the essential oil remained active in disrupting established S. aureus biofilms (IC₅₀ = 554.47 µg ml−1). No cytotoxicity was observed in human cells at the range of concentrations from 250 µg ml−1 to 1000 µg ml−1. These findings highlight Cymbopogon martini as a valuable industrial crop with potential as a plant-derived antibiofilm agent.
000168627 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B44-23R
000168627 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000168627 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000168627 700__ $$aReigada, Inés
000168627 700__ $$aAlvarado, Elena
000168627 700__ $$aGerediaga, Candela
000168627 700__ $$aYlätalo, Maarit
000168627 700__ $$0(orcid)0000-0002-9742-1463$$aSeral, Cristina$$uUniversidad de Zaragoza
000168627 700__ $$aHanski, Leena
000168627 700__ $$aLópez, Víctor
000168627 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000168627 773__ $$g239 (2026), 122479 [8 pp.]$$pInd. crops prod.$$tINDUSTRIAL CROPS AND PRODUCTS$$x0926-6690
000168627 8564_ $$s2272737$$uhttps://zaguan.unizar.es/record/168627/files/texto_completo.pdf$$yVersión publicada
000168627 8564_ $$s2626262$$uhttps://zaguan.unizar.es/record/168627/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000168627 909CO $$ooai:zaguan.unizar.es:168627$$particulos$$pdriver
000168627 951__ $$a2026-02-12-20:38:14
000168627 980__ $$aARTICLE