000168628 001__ 168628
000168628 005__ 20260217205612.0
000168628 0247_ $$2doi$$a10.1177/03009858261420280
000168628 0248_ $$2sideral$$a148019
000168628 037__ $$aART-2026-148019
000168628 041__ $$aeng
000168628 100__ $$0(orcid)0000-0002-9723-9004$$aGómez, Álex$$uUniversidad de Zaragoza
000168628 245__ $$aFirst clinicopathological characterization of body wrinkle condition in Merino sheep and its association with Orf virus infection
000168628 260__ $$c2026
000168628 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168628 5203_ $$aMerino sheep exhibit a high follicular density, enhancing wool yield but predisposing them to inherited cutaneous disorders, such as breech wrinkle, which is characterized by the appearance of multiple skin folds in the breech area. This study provides the first clinicopathological description of the so-called body wrinkle, a congenital skin condition in Merino lambs where the folds affect the whole-body skin. Four affected lambs displayed generalized alopecia with excessive skin folds. Hematological analysis showed neutrophilia, lymphopenia, and eosinopenia. Histological examination revealed follicular dysplasia, follicular keratinization and keratosis, and degeneration of follicular epithelium, particularly in the outer root sheath. The information obtained from pedigree analysis suggested an autosomal recessive inheritance pattern. All affected lambs exhibited severe OrfV lesions in the oral cavity and muzzle, persisting from 2 weeks of age until death at 1 to 2 months. Our results suggest that body wrinkle condition might favor a more prolonged clinical course and more severe outcome of OrfV infection in lambs. Further genetic and immunopathological investigations are needed.
000168628 536__ $$9info:eu-repo/grantAgreement/ES/DGA/AR15-23R
000168628 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000168628 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000168628 700__ $$0(orcid)0009-0003-9757-3840$$aQuílez, Pablo$$uUniversidad de Zaragoza
000168628 700__ $$0(orcid)0000-0002-7655-2472$$aRuiz de Arcaute, Marta$$uUniversidad de Zaragoza
000168628 700__ $$aSanz, Santiago
000168628 700__ $$aMoncayola, Irati
000168628 700__ $$aReina, Ramsés
000168628 700__ $$aPérez, Estela
000168628 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000168628 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, Lluís$$uUniversidad de Zaragoza
000168628 700__ $$0(orcid)0000-0003-0210-2919$$aMonteagudo, Luis V.$$uUniversidad de Zaragoza
000168628 700__ $$aWindsor, Peter A.
000168628 700__ $$aAsenjo, Lucía
000168628 700__ $$0(orcid)0000-0002-7822-6646$$aLacasta, Delia$$uUniversidad de Zaragoza
000168628 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000168628 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000168628 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000168628 773__ $$g(2026), [6 pp.]$$pVet. pathol.$$tVeterinary Pathology$$x0300-9858
000168628 8564_ $$s199224$$uhttps://zaguan.unizar.es/record/168628/files/texto_completo.pdf$$yPostprint
000168628 8564_ $$s792030$$uhttps://zaguan.unizar.es/record/168628/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000168628 909CO $$ooai:zaguan.unizar.es:168628$$particulos$$pdriver
000168628 951__ $$a2026-02-17-20:49:23
000168628 980__ $$aARTICLE