000168694 001__ 168694
000168694 005__ 20260218132340.0
000168694 0247_ $$2doi$$a10.1161/01.atv.19.7.1734
000168694 0248_ $$2sideral$$a176
000168694 037__ $$aART-1999-176
000168694 041__ $$aeng
000168694 100__ $$aActon, S.
000168694 245__ $$aAssociation of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population
000168694 260__ $$c1999
000168694 5060_ $$aAccess copy available to the general public$$fUnrestricted
000168694 5203_ $$aThe scavenger receptor class B type I (SR-BI) is a lipoprotein receptor that has been shown to be important in high density lipoprotein cholesterol (HDL-C) metabolism in mice. To determine its role in humans, we have characterized the human SR-BI gene and investigated its genetic variation in 489 white men and women. Five variants were demonstrated: 2 in introns (3 and 5) and 3 in exons (1, 8, and 11). Three variants at exons 1 and 8 and intron 5 with allele frequencies >0.1 were used to examine associations with lipid or anthropometric variables. The exon 1 variant was significantly (P<0.05) associated with increased HDL-C and lower low density lipoprotein cholesterol (LDL-C) values in men, but no associations were observed in women. The exon 8 variant was associated in women with lower LDL-C concentrations (3.05±0.98 mmol/L and 3.00±0.93 mmol/L for heterozygotes and homozygotes, respectively) compared with women homozygous for the common allele (3.39±1.09 mmol/L, P=0.043). No associations for this variant were observed in men. Women carriers of the intron 5 variant showed a higher body mass index (23.8±3.8 kg/m2, P=0.031) than those women homozygous for the common allele (22.4±3.4 kg/m2). Similar results were observed after haplotype analysis. Multiple regression analysis using HDL-C, LDL-C, and body mass index as dependent variables and age, sex, and each of the genetic variants as predictors also provided similar results. The associations found with both LDL-C and HDL-C suggest that SR-BI may play a role in the metabolism of both lipoprotein classes in humans.
000168694 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000168694 590__ $$a5.406$$b1999
000168694 591__ $$aPERIPHERAL VASCULAR DISEASE$$b5 / 44 = 0.114$$c1999$$dQ1$$eT1
000168694 591__ $$aHEMATOLOGY$$b5 / 59 = 0.085$$c1999$$dQ1$$eT1
000168694 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000168694 700__ $$aOsgood, D.
000168694 700__ $$aDonoghue, M.
000168694 700__ $$aCorella, D.
000168694 700__ $$0(orcid)0000-0001-8807-9187$$aPocovi, M.$$uUniversidad de Zaragoza
000168694 700__ $$0(orcid)0000-0002-6574-7303$$aCenarro, A.$$uUniversidad de Zaragoza
000168694 700__ $$0(orcid)0000-0001-5956-4319$$aMozas, P.
000168694 700__ $$aKeilty, J.
000168694 700__ $$aSquazzo, S.
000168694 700__ $$aWoolf, E. A.
000168694 700__ $$aOrdovas, J. M.
000168694 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000168694 7102_ $$13009$$2450$$aUniversidad de Zaragoza$$bDpto. Historia Moder. Contemp.$$cÁrea Historia Contemporánea
000168694 773__ $$g19, 7 (1999), 1734-1743$$pArterioscler. thromb. vasc. biol.$$tArteriosclerosis, Thrombosis, and Vascular Biology$$x1079-5642
000168694 8564_ $$s465743$$uhttps://zaguan.unizar.es/record/168694/files/texto_completo.pdf$$yPostprint
000168694 8564_ $$s2944630$$uhttps://zaguan.unizar.es/record/168694/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000168694 909CO $$ooai:zaguan.unizar.es:168694$$particulos$$pdriver
000168694 951__ $$a2026-02-18-12:27:21
000168694 980__ $$aARTICLE