168694 20260218132340.0 doi 10.1161/01.atv.19.7.1734 sideral 176 ART-1999-176 eng Acton, S. Association of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population 1999 Access copy available to the general public Unrestricted The scavenger receptor class B type I (SR-BI) is a lipoprotein receptor that has been shown to be important in high density lipoprotein cholesterol (HDL-C) metabolism in mice. To determine its role in humans, we have characterized the human SR-BI gene and investigated its genetic variation in 489 white men and women. Five variants were demonstrated: 2 in introns (3 and 5) and 3 in exons (1, 8, and 11). Three variants at exons 1 and 8 and intron 5 with allele frequencies >0.1 were used to examine associations with lipid or anthropometric variables. The exon 1 variant was significantly (P<0.05) associated with increased HDL-C and lower low density lipoprotein cholesterol (LDL-C) values in men, but no associations were observed in women. The exon 8 variant was associated in women with lower LDL-C concentrations (3.05±0.98 mmol/L and 3.00±0.93 mmol/L for heterozygotes and homozygotes, respectively) compared with women homozygous for the common allele (3.39±1.09 mmol/L, P=0.043). No associations for this variant were observed in men. Women carriers of the intron 5 variant showed a higher body mass index (23.8±3.8 kg/m2, P=0.031) than those women homozygous for the common allele (22.4±3.4 kg/m2). Similar results were observed after haplotype analysis. Multiple regression analysis using HDL-C, LDL-C, and body mass index as dependent variables and age, sex, and each of the genetic variants as predictors also provided similar results. The associations found with both LDL-C and HDL-C suggest that SR-BI may play a role in the metabolism of both lipoprotein classes in humans. info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 5.406 1999 PERIPHERAL VASCULAR DISEASE 5 / 44 = 0.114 1999 Q1 T1 HEMATOLOGY 5 / 59 = 0.085 1999 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Osgood, D. Donoghue, M. Corella, D. Pocovi, M. Universidad de Zaragoza (orcid)0000-0001-8807-9187 Cenarro, A. Universidad de Zaragoza (orcid)0000-0002-6574-7303 Mozas, P. (orcid)0000-0001-5956-4319 Keilty, J. Squazzo, S. Woolf, E. A. Ordovas, J. M. 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 3009 450 Universidad de Zaragoza Dpto. Historia Moder. Contemp. Área Historia Contemporánea 19, 7 (1999), 1734-1743 Arterioscler. thromb. vasc. biol. Arteriosclerosis, Thrombosis, and Vascular Biology 1079-5642 465743 http://zaguan.unizar.es/record/168694/files/texto_completo.pdf Postprint 2944630 http://zaguan.unizar.es/record/168694/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:168694 articulos driver 2026-02-18-12:27:21 ARTICLE