000169073 001__ 169073
000169073 005__ 20260219141447.0
000169073 0247_ $$2doi$$a10.1002/lary.28649
000169073 0248_ $$2sideral$$a117960
000169073 037__ $$aART-2021-117960
000169073 041__ $$aeng
000169073 100__ $$aAragón-Benedí, C.
000169073 245__ $$aStudy of Rocuronium–Sugammadex as an Alternative to Succinylcholine–Cisatracurium in Microlaryngeal Surgery
000169073 260__ $$c2021
000169073 5060_ $$aAccess copy available to the general public$$fUnrestricted
000169073 5203_ $$aMicrolaryngeal surgery (ML) is a short procedure that requires a deep neuromuscular blockade to provide optimum surgical conditions. Succinylcholine is a relaxant widely used but involves numerous complications. One valid alternative is rocuronium, with a specific antagonist, sugammadex. The primary objective was to assess the surgical conditions in ML according to the relaxant. The secondary objectives were to assess intubation conditions and intraoperative and immediate postoperative adverse events. Study Design: Prospective randomized study. Methods: This was a prospective study of patients scheduled for ML randomized into two groups according to relaxant. Neuromuscular blockade was recorded after administration and during ML surgery. Surgical conditions were assessed using the ML Rating Scale, intubation conditions, remifentanil doses, intraoperative complications, surgery time, emergence time, and complications in the postanesthesia care unit. Results: Two hundred five patients were included (rocuronium = 103, succinylcholine = 102). Train-of-four values were higher for rocuronium, though the otorhinolaryngology surgical conditions were significantly better in that group (rocuronium = 5.54 ± 1.39 points; succinylcholine = 9.13 ± 1.99 points). Intubation conditions were similar in both groups. Remifentanil doses were higher for succinylcholine (P <.001) (rocuronium = 0.102 ± 0.05 µg/kg/min; succinylcholine = 0.201 ± 0.05 µg/kg/min). There were no differences in the duration of surgery, but the time to awakening was significantly longer for succinylcholine (rocuronium = 3.82 ± 1.38 minutes, succinylcholine = 9.18 ± 2.04 minutes, P <.001). Conclusions: Rocuronium provides better surgical conditions and allows for the use of lower doses of remifentanil as compared to succinylcholine and cisatracurium in ML. This makes it possible to decrease the time to awakening and the complications associated with high doses of remifentanil. Level of Evidence: 1b Laryngoscope, 2020.
000169073 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B26-17D
000169073 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000169073 590__ $$a2.97$$b2021
000169073 591__ $$aOTORHINOLARYNGOLOGY$$b13 / 43 = 0.302$$c2021$$dQ2$$eT1
000169073 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b99 / 139 = 0.712$$c2021$$dQ3$$eT3
000169073 592__ $$a1.167$$b2021
000169073 593__ $$aOtorhinolaryngology$$c2021$$dQ1
000169073 594__ $$a4.7$$b2021
000169073 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000169073 700__ $$aVisiedo-Sánchez, S.
000169073 700__ $$0(orcid)0000-0001-9440-8282$$aPascual-Bellosta, A.$$uUniversidad de Zaragoza
000169073 700__ $$0(orcid)0000-0002-2378-8668$$aOrtega-Lucea, S.$$uUniversidad de Zaragoza
000169073 700__ $$0(orcid)0000-0002-6475-9361$$aFernández-Liesa, R.$$uUniversidad de Zaragoza
000169073 700__ $$0(orcid)0000-0003-2462-1904$$aMartínez-Ubieto, J.$$uUniversidad de Zaragoza
000169073 700__ $$0(orcid)0000-0002-6314-551X$$aJiménez Bernardó, María Teresa$$uUniversidad de Zaragoza
000169073 700__ $$0(orcid)0000-0003-1174-0525$$aMuñoz Rodríguez, Luis Alfonso$$uUniversidad de Zaragoza
000169073 700__ $$aGil Bona, Jesús$$uUniversidad de Zaragoza
000169073 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000169073 7102_ $$11013$$2653$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Otorrinolaringología
000169073 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000169073 773__ $$g131, 1 (2021), E212-E218$$pLaryngoscope$$tLaryngoscope$$x0023-852X
000169073 8564_ $$s989304$$uhttps://zaguan.unizar.es/record/169073/files/texto_completo.pdf$$yPostprint
000169073 8564_ $$s1251558$$uhttps://zaguan.unizar.es/record/169073/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000169073 909CO $$ooai:zaguan.unizar.es:169073$$particulos$$pdriver
000169073 951__ $$a2026-02-19-14:14:09
000169073 980__ $$aARTICLE