169073 20260219141447.0 doi 10.1002/lary.28649 sideral 117960 ART-2021-117960 eng Aragón-Benedí, C. Study of Rocuronium–Sugammadex as an Alternative to Succinylcholine–Cisatracurium in Microlaryngeal Surgery 2021 Access copy available to the general public Unrestricted Microlaryngeal surgery (ML) is a short procedure that requires a deep neuromuscular blockade to provide optimum surgical conditions. Succinylcholine is a relaxant widely used but involves numerous complications. One valid alternative is rocuronium, with a specific antagonist, sugammadex. The primary objective was to assess the surgical conditions in ML according to the relaxant. The secondary objectives were to assess intubation conditions and intraoperative and immediate postoperative adverse events. Study Design: Prospective randomized study. Methods: This was a prospective study of patients scheduled for ML randomized into two groups according to relaxant. Neuromuscular blockade was recorded after administration and during ML surgery. Surgical conditions were assessed using the ML Rating Scale, intubation conditions, remifentanil doses, intraoperative complications, surgery time, emergence time, and complications in the postanesthesia care unit. Results: Two hundred five patients were included (rocuronium = 103, succinylcholine = 102). Train-of-four values were higher for rocuronium, though the otorhinolaryngology surgical conditions were significantly better in that group (rocuronium = 5.54 ± 1.39 points; succinylcholine = 9.13 ± 1.99 points). Intubation conditions were similar in both groups. Remifentanil doses were higher for succinylcholine (P <.001) (rocuronium = 0.102 ± 0.05 µg/kg/min; succinylcholine = 0.201 ± 0.05 µg/kg/min). There were no differences in the duration of surgery, but the time to awakening was significantly longer for succinylcholine (rocuronium = 3.82 ± 1.38 minutes, succinylcholine = 9.18 ± 2.04 minutes, P <.001). Conclusions: Rocuronium provides better surgical conditions and allows for the use of lower doses of remifentanil as compared to succinylcholine and cisatracurium in ML. This makes it possible to decrease the time to awakening and the complications associated with high doses of remifentanil. Level of Evidence: 1b Laryngoscope, 2020. info:eu-repo/grantAgreement/ES/DGA-FEDER/B26-17D info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 2.97 2021 OTORHINOLARYNGOLOGY 13 / 43 = 0.302 2021 Q2 T1 MEDICINE, RESEARCH & EXPERIMENTAL 99 / 139 = 0.712 2021 Q3 T3 1.167 2021 Otorhinolaryngology 2021 Q1 4.7 2021 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Visiedo-Sánchez, S. Pascual-Bellosta, A. Universidad de Zaragoza (orcid)0000-0001-9440-8282 Ortega-Lucea, S. Universidad de Zaragoza (orcid)0000-0002-2378-8668 Fernández-Liesa, R. Universidad de Zaragoza (orcid)0000-0002-6475-9361 Martínez-Ubieto, J. Universidad de Zaragoza (orcid)0000-0003-2462-1904 Jiménez Bernardó, María Teresa Universidad de Zaragoza (orcid)0000-0002-6314-551X Muñoz Rodríguez, Luis Alfonso Universidad de Zaragoza (orcid)0000-0003-1174-0525 Gil Bona, Jesús Universidad de Zaragoza 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1013 653 Universidad de Zaragoza Dpto. Cirugía Área Otorrinolaringología 1013 090 Universidad de Zaragoza Dpto. Cirugía Área Cirugía 131, 1 (2021), E212-E218 Laryngoscope Laryngoscope 0023-852X 989304 http://zaguan.unizar.es/record/169073/files/texto_completo.pdf Postprint 1251558 http://zaguan.unizar.es/record/169073/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:169073 articulos driver 2026-02-19-14:14:09 ARTICLE