000169083 001__ 169083
000169083 005__ 20260218135106.0
000169083 0247_ $$2doi$$a10.3390/biomedicines10092201
000169083 0248_ $$2sideral$$a148105
000169083 037__ $$aART-2022-148105
000169083 041__ $$aeng
000169083 100__ $$0(orcid)0000-0002-6811-6654$$aGascón-Ruiz, Marta
000169083 245__ $$aDiagnosis of Malnutrition According to GLIM Criteria Predicts Complications and 6-Month Survival in Cancer Outpatients
000169083 260__ $$c2022
000169083 5060_ $$aAccess copy available to the general public$$fUnrestricted
000169083 5203_ $$aBackground and Aims: Malnutrition is a condition that has a great impact on oncology patients. Poor nutritional status is often associated with increased morbidity and mortality, increased toxicity, and reduced tolerance to chemotherapy, among other complications. The recently developed GLIM criteria for malnutrition aim to homogenize its diagnosis, considering the baseline disease status. We aimed to evaluate the performance of these new criteria for the prediction of complications and mortality in patients with cancer.
Methods: This work is a prospective, single-center study. All outpatients under active treatment for head and neck, upper gastrointestinal, and colorectal tumors between February and October 2020 were recruited. These patients were followed up for 6 months, assessing the occurrence of complications and survival based on GLIM diagnoses of malnutrition.
Results: We enrolled 165 outpatients, 46.66% of whom were malnourished. During the 6-month follow-ups, patients with malnutrition (46.7%, according to GLIM criteria) had a ~3-fold increased risk of hospital admission (p < 0.001) and occurrence of severe infection (considered as those requiring hospitalization, intravenous antibiotics, and/or drainage by interventional procedures) (p = 0.002). Similarly, malnourished patients had a 3.5-fold increased risk of poor pain control and a 4.4-fold increased need for higher doses of opioids (both p < 0.001). They also had a 2.6-fold increased risk of toxicity (p = 0.044) and a 2.5-fold increased likelihood of needing a dose decrease or discontinuation of cancer treatment (p = 0.011). The 6-month survival of malnourished patients was significantly lower (p = 0.023) than in non-malnourished patients.
Conclusions: Diagnoses of malnutrition according to the GLIM criteria in oncology patients undergoing active treatment predict increased complications and worse survival at 6-month follow-ups, making them a useful tool for assessing the nutritional status of oncology patients.
000169083 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B03-20R$$9info:eu-repo/grantAgreement/ES/ISCIII/FEDER/PI17-02268
000169083 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000169083 590__ $$a4.7$$b2022
000169083 591__ $$aPHARMACOLOGY & PHARMACY$$b68 / 278 = 0.245$$c2022$$dQ1$$eT1
000169083 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b92 / 285 = 0.323$$c2022$$dQ2$$eT1
000169083 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b54 / 136 = 0.397$$c2022$$dQ2$$eT2
000169083 592__ $$a0.897$$b2022
000169083 593__ $$aMedicine (miscellaneous)$$c2022$$dQ1
000169083 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2022$$dQ2
000169083 594__ $$a3.7$$b2022
000169083 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000169083 700__ $$0(orcid)0000-0001-6883-8940$$aCasas-Deza, Diego
000169083 700__ $$aMarti-Pi, María
000169083 700__ $$0(orcid)0000-0003-3387-0558$$aTorres-Ramón, Irene
000169083 700__ $$aZapata-García, María
000169083 700__ $$aSesma, Andrea
000169083 700__ $$0(orcid)0000-0003-0063-1067$$aLambea, Julio$$uUniversidad de Zaragoza
000169083 700__ $$aÁlvarez-Alejandro, María
000169083 700__ $$aQuilez, Elisa
000169083 700__ $$aIsla, Dolores
000169083 700__ $$0(orcid)0000-0002-8982-3737$$aArbonés-Mainar, Jose Miguel
000169083 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000169083 773__ $$g10, 9 (2022), 2201 [10 pp.]$$tBiomedicines$$x2227-9059
000169083 8564_ $$s570970$$uhttps://zaguan.unizar.es/record/169083/files/texto_completo.pdf$$yVersión publicada
000169083 8564_ $$s2764994$$uhttps://zaguan.unizar.es/record/169083/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000169083 909CO $$ooai:zaguan.unizar.es:169083$$particulos$$pdriver
000169083 951__ $$a2026-02-18-12:23:57
000169083 980__ $$aARTICLE