000169099 001__ 169099
000169099 005__ 20260219091139.0
000169099 0247_ $$2doi$$a10.1002/adfm.202529076
000169099 0248_ $$2sideral$$a148181
000169099 037__ $$aART-2026-148181
000169099 041__ $$aeng
000169099 100__ $$aDel Sol-Fernández, Susel
000169099 245__ $$aMagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells
000169099 260__ $$c2026
000169099 5060_ $$aAccess copy available to the general public$$fUnrestricted
000169099 5203_ $$aThis study introduces MagPiezo, a novel magnetogenetic platform designed to enable remote and targeted manipulation of endogenous Piezo1 channels without genetic modification in vitro. MagPiezo integrates a custom-built magnetic applicator and 19 nm octahedral mixed ferrite nanoparticles (MF) with enhanced magnetocrystalline anisotropy, engineered to selectively target Piezo1 channels. The application of a low intensity (< 40 mT), low frequency (0.5 Hz) magnetic field is sufficient to generate wireless torque forces in the piconewton range capable of gating Piezo1 channels in vitro. Remarkably, MagPiezo induces robust responses in endothelial cells, including calcium influx, cytoskeletal reorganization and transcriptional activation. Unlike other magnetogenetic tools, MagPiezo avoids the need to assemble the magnetic nanoparticles (MNPs) into bigger beads to reach the opening threshold and does not need to genetically engineer Piezo1 channels. Moreover, it uses low magnetic field intensities and frequencies, enhancing its potential for in vivo translation. Therefore, MagPiezo is a powerful platform for manipulating Piezo1 channels and dissecting mechanotransduction events in vascular biology, paving the way for new strategies to modulate mechanoreceptors.
000169099 536__ $$9info:eu-repo/grantAgreement/ES/AEI/CEX2023-001286-S$$9info:eu-repo/grantAgreement/ES/DGA/E15-23R$$9info:eu-repo/grantAgreement/EC/EU/HORIZON/MSCA-2021-PF-01-01$$9info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101064735/EU/Tunning the force for remote magnetomechanical gating of Piezo1 channels/MAGPIEZ$$9info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101081713/EU/Intelligent Device and Computational Software to Control Mechanical Stress and Deformation for Biological Testing/ISBIOMECH$$9info:eu-repo/grantAgreement/EC/H2020/101034263/EU/ COMFUTURO, a public-private collaboration committed to science and the future/COMFUTURO$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101034263-COMFUTURO$$9info:eu-repo/grantAgreement/EC/H2020/853468/EU/Remote control of cellular signalling triggered by magnetic switching/SIROCCO$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 853468-SIROCCO$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-122508NB-I00
000169099 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000169099 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000169099 700__ $$aDe Simone, Mariarosaria
000169099 700__ $$0(orcid)0000-0002-0970-1917$$aFernández-Afonso, Yilian
000169099 700__ $$aGarcia-Gonzalez, Daniel
000169099 700__ $$aMartínez-Vicente, Pablo$$uUniversidad de Zaragoza
000169099 700__ $$0(orcid)0000-0002-8810-7149$$avan Zanten, Thomas
000169099 700__ $$0(orcid)0000-0001-5559-8757$$aFratila, Raluca M.
000169099 700__ $$0(orcid)0000-0002-2861-2469$$aMoros, Maria
000169099 7102_ $$11003$$2027$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Anatom.Embriol.Humana
000169099 773__ $$g(2026), e29076 [20 pp.]$$pAdv. funct. mater.$$tAdvanced Functional Materials$$x1616-301X
000169099 8564_ $$s4180677$$uhttps://zaguan.unizar.es/record/169099/files/texto_completo.pdf$$yVersión publicada
000169099 8564_ $$s2338644$$uhttps://zaguan.unizar.es/record/169099/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000169099 909CO $$ooai:zaguan.unizar.es:169099$$particulos$$pdriver
000169099 951__ $$a2026-02-19-08:43:12
000169099 980__ $$aARTICLE