000169177 001__ 169177
000169177 005__ 20260223164758.0
000169177 0247_ $$2doi$$a10.1111/dth.15142
000169177 0248_ $$2sideral$$a127169
000169177 037__ $$aART-2021-127169
000169177 041__ $$aeng
000169177 100__ $$aGarcía-Gil, Miguel Fernando
000169177 245__ $$aNo antibody response in cutaneous manifestations associated with COVID-19: An observational study of 64 cases with microbiological and clinical characterization
000169177 260__ $$c2021
000169177 5203_ $$aBackground: The microbiological diagnosis of skin lesions related to COVID-19 is not well known. Objective: Perform a microbiological diagnosis in COVID19-related cutaneous manifestations. Methods: A cross-sectional study was performed with 64 patients with cutaneous manifestations associated with COVID-19 who under- went serological and nasopharyngeal reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. Results: Out of the 64 patients, 6 patients had positive RT-PCR, with all of them developing SARS-CoV-2 IgG and 4 of them had positive IgM + IgA. Of the 58 patients with negative RT-PCR, 8 cases had positive IgM + IgA and only one of them had IgG seroconversion. Therefore, the infection was demon- strated in 7 cases (10.9%) and was doubtful in 7 other cases (10.9%) who presented negative RT-PCR and presence of IgA + IgM without subsequent seroconversion of IgG. Fifty patients (78.1%) had negative serological tests. The most frequent cutane- ous pattern was pseudo-chilblain (48.4%) followed by maculo-papular pattern (26.6%), urticarial lesions (10.9%), vesicular eruptions (6.3%) and livedoid pattern (4.7%). The maculo-papular pattern showed the highest positivity in RT-PCR (3 cases; 17.6%) and serologies (4 cases; 23.5%). Skin lesions developed after the systemic symptoms in most patients (19 cases; 61.3%). Conclusions: Microbiological confirma- tion tests may not be an effective diagnostic technique for COVID-related cutaneous manifestations or that attributed lesions are not related to COVID-19. Confounding fac- tors such as adverse drug reaction, serological cross-reactions with other viruses, the low production of antibodies in asymptomatic or mild forms of COVID-19 or its rapid disap- pearance, increase diagnostic uncertainty.
000169177 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000169177 590__ $$a3.858$$b2021
000169177 591__ $$aDERMATOLOGY$$b19 / 69 = 0.275$$c2021$$dQ2$$eT1
000169177 592__ $$a0.598$$b2021
000169177 593__ $$aMedicine (miscellaneous)$$c2021$$dQ2
000169177 593__ $$aDermatology$$c2021$$dQ2
000169177 594__ $$a3.1$$b2021
000169177 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000169177 700__ $$aMonte-Serrano, Juan
000169177 700__ $$aLapeña-Casado, Alejandro
000169177 700__ $$aVillagrasa-Boli, Pablo
000169177 700__ $$aRamírez-Lluch, Mar
000169177 700__ $$aMartínez-Pallás, Isabel
000169177 700__ $$aBularca, Aura
000169177 700__ $$aAldea-Manrique, Beatriz
000169177 700__ $$0(orcid)0000-0001-5134-1006$$aBenito-Ruesca, Rafael$$uUniversidad de Zaragoza
000169177 700__ $$0(orcid)0000-0001-9404-1126$$aVentura-Faci, María Purificación$$uUniversidad de Zaragoza
000169177 700__ $$0(orcid)0000-0001-8789-6783$$aAra-Martín, Mariano$$uUniversidad de Zaragoza
000169177 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000169177 7102_ $$11007$$2183$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cÁrea Dermatología
000169177 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000169177 773__ $$g34, 6 (2021), e15142 [5 pp.]$$pDermatologic Therapy$$tDermatologic Therapy$$x1396-0296
000169177 8564_ $$s1183789$$uhttps://zaguan.unizar.es/record/169177/files/texto_completo.pdf$$yVersión publicada
000169177 8564_ $$s1995739$$uhttps://zaguan.unizar.es/record/169177/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000169177 909CO $$ooai:zaguan.unizar.es:169177$$particulos$$pdriver
000169177 951__ $$a2026-02-23-14:53:52
000169177 980__ $$aARTICLE