169177 20260223164758.0 doi 10.1111/dth.15142 sideral 127169 ART-2021-127169 eng García-Gil, Miguel Fernando No antibody response in cutaneous manifestations associated with COVID-19: An observational study of 64 cases with microbiological and clinical characterization 2021 Background: The microbiological diagnosis of skin lesions related to COVID-19 is not well known. Objective: Perform a microbiological diagnosis in COVID19-related cutaneous manifestations. Methods: A cross-sectional study was performed with 64 patients with cutaneous manifestations associated with COVID-19 who under- went serological and nasopharyngeal reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2. Results: Out of the 64 patients, 6 patients had positive RT-PCR, with all of them developing SARS-CoV-2 IgG and 4 of them had positive IgM + IgA. Of the 58 patients with negative RT-PCR, 8 cases had positive IgM + IgA and only one of them had IgG seroconversion. Therefore, the infection was demon- strated in 7 cases (10.9%) and was doubtful in 7 other cases (10.9%) who presented negative RT-PCR and presence of IgA + IgM without subsequent seroconversion of IgG. Fifty patients (78.1%) had negative serological tests. The most frequent cutane- ous pattern was pseudo-chilblain (48.4%) followed by maculo-papular pattern (26.6%), urticarial lesions (10.9%), vesicular eruptions (6.3%) and livedoid pattern (4.7%). The maculo-papular pattern showed the highest positivity in RT-PCR (3 cases; 17.6%) and serologies (4 cases; 23.5%). Skin lesions developed after the systemic symptoms in most patients (19 cases; 61.3%). Conclusions: Microbiological confirma- tion tests may not be an effective diagnostic technique for COVID-related cutaneous manifestations or that attributed lesions are not related to COVID-19. Confounding fac- tors such as adverse drug reaction, serological cross-reactions with other viruses, the low production of antibodies in asymptomatic or mild forms of COVID-19 or its rapid disap- pearance, increase diagnostic uncertainty. info:eu-repo/semantics/closedAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.858 2021 DERMATOLOGY 19 / 69 = 0.275 2021 Q2 T1 0.598 2021 Medicine (miscellaneous) 2021 Q2 Dermatology 2021 Q2 3.1 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Monte-Serrano, Juan Lapeña-Casado, Alejandro Villagrasa-Boli, Pablo Ramírez-Lluch, Mar Martínez-Pallás, Isabel Bularca, Aura Aldea-Manrique, Beatriz Benito-Ruesca, Rafael Universidad de Zaragoza (orcid)0000-0001-5134-1006 Ventura-Faci, María Purificación Universidad de Zaragoza (orcid)0000-0001-9404-1126 Ara-Martín, Mariano Universidad de Zaragoza (orcid)0000-0001-8789-6783 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1007 183 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Área Dermatología 1011 670 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Pediatría 34, 6 (2021), e15142 [5 pp.] Dermatologic Therapy Dermatologic Therapy 1396-0296 1183789 http://zaguan.unizar.es/record/169177/files/texto_completo.pdf Versión publicada 1995739 http://zaguan.unizar.es/record/169177/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:169177 articulos driver 2026-02-23-14:53:52 ARTICLE