000169199 001__ 169199
000169199 005__ 20260223164759.0
000169199 0247_ $$2doi$$a10.1007/s11357-026-02145-7
000169199 0248_ $$2sideral$$a148287
000169199 037__ $$aART-2026-148287
000169199 041__ $$aeng
000169199 100__ $$0(orcid)0000-0002-1252-2397$$aLobo, Elena$$uUniversidad de Zaragoza
000169199 245__ $$aDifferences across males and females in cognitive aging and mortality risk: a trajectory-based approach
000169199 260__ $$c2026
000169199 5060_ $$aAccess copy available to the general public$$fUnrestricted
000169199 5203_ $$aThis study examined hypothesized differences across males and females in the relationship between cognitive trajectories and mortality in older adults. Data were drawn from the ZARADEMP study on dementia and depression in adults aged 55 and older in Zaragoza, Spain. A total of 2403 cognitively healthy individuals who completed at least three of four waves over a 12-year follow-up were included. Cognitive trajectories were derived from Mini-Mental State Examination (MMSE) scores. Using growth mixture modeling (GMM), four trajectories in men and three in women were previously identified. Mortality data, obtained from official records, covered up to 6 years after the final wave. Cox proportional hazards models assessed mortality risk across trajectories, adjusting for sociodemographic, medical, and lifestyle factors. Mortality was higher among participants with steeper cognitive decline in both sexes. In men, those in the declining-low and stable-medium trajectories had 133% and 36% higher mortality risk, respectively, compared to the stable-high group. In women, declining-low and stable-medium classes had 133% and 30% increased risk, respectively. The association in women followed a clear gradient; in men, this pattern was absent. Differences in mortality predictors were identified: medical conditions (e.g., hypertension, diabetes, alcohol use) were significant only in men, whereas psychosocial and functional variables (e.g., anxiety, ADL dependency, marital status) were significant only in women. This is the first report showing differences across males and females in the association between cognitive decline trajectories and mortality. Sex-specific strategies may be needed to mitigate mortality associated with trajectories of cognitive decline.
000169199 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI-19-01874$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/98-0103$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254
000169199 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000169199 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000169199 700__ $$0(orcid)0000-0003-2284-7862$$aCámara, Concepción de la$$uUniversidad de Zaragoza
000169199 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, Patricia$$uUniversidad de Zaragoza
000169199 700__ $$0(orcid)0000-0002-3360-7015$$aLópez-Antón, Raúl$$uUniversidad de Zaragoza
000169199 700__ $$0(orcid)0000-0002-6427-6845$$aSaz, Pedro$$uUniversidad de Zaragoza
000169199 700__ $$aVaquero-Puyuelo, David$$uUniversidad de Zaragoza
000169199 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000169199 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000169199 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000169199 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000169199 773__ $$g(2026), [13 pp.]$$pGeroScience$$tGeroScience$$x2509-2715
000169199 8564_ $$s672347$$uhttps://zaguan.unizar.es/record/169199/files/texto_completo.pdf$$yVersión publicada
000169199 8564_ $$s1650689$$uhttps://zaguan.unizar.es/record/169199/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000169199 909CO $$ooai:zaguan.unizar.es:169199$$particulos$$pdriver
000169199 951__ $$a2026-02-23-14:54:21
000169199 980__ $$aARTICLE