000169334 001__ 169334 000169334 005__ 20260225105428.0 000169334 0247_ $$2doi$$a10.1097/PAS.0000000000001186 000169334 0248_ $$2sideral$$a110918 000169334 037__ $$aART-2019-110918 000169334 041__ $$aeng 000169334 100__ $$aPrieto-Torres, L. 000169334 245__ $$aThe spectrum of EBV-positive mucocutaneous ulcer 000169334 260__ $$c2019 000169334 5203_ $$aWe describe a series of 9 patients with Epstein-Barr virus (EBV)-positive mucocutaneous lymphoproliferative lesions that broadens the concept of EBV-positive mucocutaneous ulcer. We report 5 female and 4 male patients, with an average age of 74 years (range, 55 to 87 y), 2 of whom were HIV-positive. The lesions were located in the oropharynx, skin, and rectal and/or genital mucosa. Histopathologically, 6 cases showed a polymorphic pattern and 3 had a monomorphic and diffuse one, with angiotropism in 4 cases (2 each with the polymorphic and monomorphic patterns). Three of the cases expressed PDL1. In addition to its presence in the neoplastic lymphoid cells, EBV was also detected in adjacent epithelial cells in an oropharyngeal lesion. All cases responded to local therapy or adapted systemic chemotherapy in selected cases. This series extends the spectrum of this disorder to include some HIV-positive cases, patients with multiple lesions confined to a single anatomic area, lesions with an angiocentric pattern, and some cases with monomorphous large-cell cytology. We discuss the differential clinicopathologic diagnosis of this disorder and that of classic EBV large B-cell lymphoma. Copyright 000169334 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000169334 590__ $$a4.958$$b2019 000169334 591__ $$aSURGERY$$b10 / 209 = 0.048$$c2019$$dQ1$$eT1 000169334 591__ $$aPATHOLOGY$$b10 / 78 = 0.128$$c2019$$dQ1$$eT1 000169334 592__ $$a2.734$$b2019 000169334 593__ $$aAnatomy$$c2019$$dQ1 000169334 593__ $$aSurgery$$c2019$$dQ1 000169334 593__ $$aPathology and Forensic Medicine$$c2019$$dQ1 000169334 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000169334 700__ $$aEraña, I. 000169334 700__ $$aGil-Redondo, R. 000169334 700__ $$aGómez De La Riva, I. 000169334 700__ $$aManso, R. 000169334 700__ $$aPajares, R. 000169334 700__ $$aCórdoba, R. 000169334 700__ $$aMachan, S. 000169334 700__ $$0(orcid)0000-0001-8789-6783$$aAra, M.$$uUniversidad de Zaragoza 000169334 700__ $$aRequena, L. 000169334 700__ $$aPiris, M.Á. 000169334 700__ $$aRodríguez-Pinilla, S.M. 000169334 7102_ $$11007$$2183$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cÁrea Dermatología 000169334 773__ $$g43, 2 (2019), 201-210$$pAm. j. surg. pathol.$$tAMERICAN JOURNAL OF SURGICAL PATHOLOGY$$x0147-5185 000169334 8564_ $$s649814$$uhttps://zaguan.unizar.es/record/169334/files/texto_completo.pdf$$yVersión publicada 000169334 8564_ $$s3241574$$uhttps://zaguan.unizar.es/record/169334/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000169334 909CO $$ooai:zaguan.unizar.es:169334$$particulos$$pdriver 000169334 951__ $$a2026-02-24-14:46:55 000169334 980__ $$aARTICLE