000169342 001__ 169342
000169342 005__ 20260225105429.0
000169342 0247_ $$2doi$$a10.1155/2014/651501
000169342 0248_ $$2sideral$$a148311
000169342 037__ $$aART-2014-148311
000169342 041__ $$aeng
000169342 100__ $$aPastushenko, Ievgenia
000169342 245__ $$aSquamous Cell Carcinomas of the Skin Explore Angiogenesis-Independent Mechanisms of Tumour Vascularization
000169342 260__ $$c2014
000169342 5060_ $$aAccess copy available to the general public$$fUnrestricted
000169342 5203_ $$aAims.To evaluate the vascularization in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) of the skin.Methods.We performed CD31 (i.e., panendothelial marker) and CD105 (i.e., proliferating endothelium marker) immunostaining on samples of 70 SCCs and 70 BCCs of the skin. We evaluated the relative blood vessel area using the Chalkley counting method in each histologic subtype of these tumours. We calculated the degree of proliferation of blood vessel endothelium dividing CD105-Chalkley score by CD31-Chalkley score.Results.We found significantly higher peritumoral and intratumoral blood vessel area in SCC when compared to BCC (both with CD31 and CD105). Chalkley counts differed significantly between groups with different BCC histologic subtypes and SCC with different grade of differentiation. Surprisingly, the degree of proliferation of blood vessel endothelium was higher in BCC when compared to SCC.Conclusions.While SCC exhibited significantly higher intratumoral and peritumoral blood vessel areas compared to BCC, the relatively low rate of proliferating endothelium in this tumour type suggests the existence of endothelial-sprouting-independent mechanisms of vascularization in SCC.
000169342 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000169342 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000169342 700__ $$aGracia-Cazaña, Tamara
000169342 700__ $$aVicente-Arregui, Sandra
000169342 700__ $$aVan den Eynden, Gert G.
000169342 700__ $$0(orcid)0000-0001-8789-6783$$aAra, Mariano$$uUniversidad de Zaragoza
000169342 700__ $$aVermeulen, Peter B.
000169342 700__ $$0(orcid)0000-0002-4083-0792$$aCarapeto, Franciso José$$uUniversidad de Zaragoza
000169342 700__ $$aVan Laere, Steven J.
000169342 7102_ $$11007$$2183$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cÁrea Dermatología
000169342 773__ $$g2014 (2014), 1-5$$tJournal of Skin Cancer$$x2090-2913
000169342 8564_ $$s3817764$$uhttps://zaguan.unizar.es/record/169342/files/texto_completo.pdf$$yVersión publicada
000169342 8564_ $$s2345223$$uhttps://zaguan.unizar.es/record/169342/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000169342 909CO $$ooai:zaguan.unizar.es:169342$$particulos$$pdriver
000169342 951__ $$a2026-02-24-14:47:07
000169342 980__ $$aARTICLE