000169372 001__ 169372
000169372 005__ 20260225105429.0
000169372 0247_ $$2doi$$a10.2807/1560-7917.ES.2025.30.44.2500254
000169372 0248_ $$2sideral$$a148271
000169372 037__ $$aART-2025-148271
000169372 041__ $$aeng
000169372 100__ $$aPereira, Sara
000169372 245__ $$aHepatitis E virus screening in solid organ transplant recipients: prevalence and implications for implementation, Spain, 2021 to 2023
000169372 260__ $$c2025
000169372 5060_ $$aAccess copy available to the general public$$fUnrestricted
000169372 5203_ $$aINTRODUCTION: In solid organ transplant (SOT) recipients, hepatitis E virus (HEV) poses a complex clinical challenge, because there is a risk of developing persistent infection. Current European guidelines recommend the screening of HEV in SOT recipients because of the risk of unrecognised infection. Despite these recommendations, routine screening for HEV remains underutilised in clinical practice.
AIM: Our study aimed to determine the prevalence of HEV viraemia and to evaluate the clinical evolution of HEV infection in SOT.
METHODS: We performed a multicentre cross-sectional study including adult SOT recipients under follow-up in Spain. All patients were prospectively tested for HEV RNA in peripheral blood. Individuals with detectable viraemia were prospectively followed up every 3 months to evaluate viral persistence.
RESULTS: A total of 940 patients were included in the study. Five patients were infected, supposing a prevalence of HEV infection in Spanish SOT recipients of 0.53% (95% confidence interval: 0.23–1.24). Genotyping was successfully conducted in four cases, all identified as genotype 3. All patients were asymptomatic and had varied levels of liver enzyme elevations. At follow-up, three of the five patients remained HEC RNA-positive, consistent with chronic infection. Overall, the prevalence of chronic HEV infection in our study population was 0.32%.
CONCLUSION: Our study highlights the need to establish periodic molecular HEV surveillance in SOT recipients.
000169372 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF/IFI14-00007$$9info:eu-repo/grantAgreement/ES/ISCIII/PI22-01098
000169372 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000169372 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000169372 700__ $$aPérez-Rivilla, Alfredo
000169372 700__ $$aCarracedo, Raquel
000169372 700__ $$aLópez-López, Pedro
000169372 700__ $$aRodríguez-Iglesias, Manuel
000169372 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, Rafael
000169372 700__ $$aFuentes, Ana
000169372 700__ $$aLópez-Ruz, Miguel Ángel
000169372 700__ $$aFreyre-Carrillo, Carolina
000169372 700__ $$aDel Valle Odero, María
000169372 700__ $$aParajó, Noelia
000169372 700__ $$aGarcía, Federico
000169372 700__ $$aRivero, Antonio
000169372 700__ $$aRivero-Juárez, Antonio
000169372 700__ $$aAguilera, Antonio
000169372 773__ $$g30, 44 (2025), 8$$pEurosurveillance$$tEurosurveillance$$x1025-496X
000169372 8564_ $$s756350$$uhttps://zaguan.unizar.es/record/169372/files/texto_completo.pdf$$yVersión publicada
000169372 8564_ $$s3301551$$uhttps://zaguan.unizar.es/record/169372/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000169372 909CO $$ooai:zaguan.unizar.es:169372$$particulos$$pdriver
000169372 951__ $$a2026-02-24-14:47:45
000169372 980__ $$aARTICLE