000169374 001__ 169374
000169374 005__ 20260225105429.0
000169374 0247_ $$2doi$$a10.1016/j.suronc.2026.102369
000169374 0248_ $$2sideral$$a148314
000169374 037__ $$aART-2026-148314
000169374 041__ $$aeng
000169374 100__ $$aOtero-Romero, Daniel$$uUniversidad de Zaragoza
000169374 245__ $$aThe modified 5-item frailty index predicts long-term mortality after breast cancer surgery in elderly women: A five-year follow-up study
000169374 260__ $$c2026
000169374 5060_ $$aAccess copy available to the general public$$fUnrestricted
000169374 5203_ $$aPurpose: Frailty is a major determinant of outcomes in older adults with cancer, and its identification in surgical oncology patients provides an opportunity to enhance perioperative care. However, the association of frailty with long-term outcomes remains poorly characterized. This study evaluated the prognostic value of the modified 5-item frailty index (mFI-5) in predicting long-term survival among elderly women undergoing breast cancer surgery. Methods: A retrospective observational study was conducted including 290 women aged ≥70 years who underwent breast cancer surgery between 2016 and 2021. Frailty was assessed using the mFI-5 and categorized as fit (score = 0), pre-frail (score = 1), and frail (score ≥2). Long-term survival rates were analyzed across age groups, tumor subtypes, and TNM stages, stratified by mFI-5 category. Results: Frailty was identified in 37.2% of patients and was strongly associated with reduced long-term overall survival (52.6% in frail vs. 88.4% in fit patients at 5 years). Multivariable Cox regression confirmed frailty as an independent predictor of mortality (HR 3.14, p = 0.003), primarily driven by non-cancer related deaths. The prognostic performance of the mFI-5 was consistent across all subgroups analyzed. Conclusion: The mFI-5 is a simple and practical tool that identifies elderly women with breast cancer at increased risk of long-term mortality following surgery. Incorporating the mFI-5 into routine preoperative evaluation may facilitate improved treatment planning and outcomes.
000169374 540__ $$9info:eu-repo/semantics/embargoedAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000169374 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000169374 700__ $$0(orcid)0000-0002-3592-820X$$aArribas-del-Amo, Dolores$$uUniversidad de Zaragoza
000169374 7102_ $$11013$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Cirugía
000169374 773__ $$g65 (2026), 102369 [6 pp.]$$pSurg. oncol.$$tSURGICAL ONCOLOGY-OXFORD$$x0960-7404
000169374 8564_ $$s1275044$$uhttps://zaguan.unizar.es/record/169374/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2027-02-12
000169374 8564_ $$s497884$$uhttps://zaguan.unizar.es/record/169374/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2027-02-12
000169374 909CO $$ooai:zaguan.unizar.es:169374$$particulos$$pdriver
000169374 951__ $$a2026-02-24-14:47:47
000169374 980__ $$aARTICLE