169434 20260227133540.0 doi 10.1021/acs.orglett.9b01993 sideral 113166 ART-2019-113166 eng Alvarez-Perez, A. Ruthenium-Catalyzed Oxidative Amidation of Alkynes to Amides 2019 Complex CpRuCl(PPh3)(2) catalyzes reactions of terminal alkynes with 4-picoline N-oxide and primary and secondary amines to afford the corresponding amides. The reactions occur in chlorinated solvent and aqueous medium, showing applications in peptide chemistry. Stoichiometric studies reveal that the true catalysts of the processes are the vinylidene cations [CpRu(=C=CHR)(PPh3)(2)](+) which are oxidized to the Ru(eta(2)-CO)-ketenes by the N-oxide. Finally, nucleophilic additions of primary and secondary amines to the free ketenes yield the corresponding amides. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/E06-17R info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-59015-R info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-82935-P info:eu-repo/grantAgreement/ES/MINECO/CTQ2017-87939-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 6.091 2019 CHEMISTRY, ORGANIC 4 / 57 = 0.07 2019 Q1 T1 2.032 2019 Biochemistry 2019 Q1 Physical and Theoretical Chemistry 2019 Q1 Organic Chemistry 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Esteruelas, M.A. (orcid)0000-0002-4829-7590 Izquierdo, S. (orcid)0000-0002-6608-1910 Varela, J.A. Saa, C. 21, 13 (2019), 5346-5350 Org. lett. ORGANIC LETTERS 1523-7060 304258 http://zaguan.unizar.es/record/169434/files/texto_completo.pdf Postprint 2571894 http://zaguan.unizar.es/record/169434/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:169434 articulos driver 2026-02-27-12:35:34 ARTICLE