000169987 001__ 169987
000169987 005__ 20260318135944.0
000169987 0247_ $$2doi$$a10.1007/s15010-025-02681-y
000169987 0248_ $$2sideral$$a148623
000169987 037__ $$aART-2025-148623
000169987 041__ $$aeng
000169987 100__ $$aGupta, Nitin
000169987 245__ $$aEndemic avian influenza landscape in Asia: sustained zoonotic risks
000169987 260__ $$c2025
000169987 5060_ $$aAccess copy available to the general public$$fUnrestricted
000169987 5203_ $$aAvian influenza remains a persistent global health threat, with Asia at its epicentre due to dense poultry production, live bird markets, and cross-species interfaces with ducks and swine. Several pathogenic subtypes continue to cause recurrent zoonotic spillovers with varying human case fatality, reinforcing the region’s role as a pandemic hotspot. Surveillance highlights the main key ecological drivers: sustained viral circulation in live bird markets, subclinical infection in domestic ducks, wild birds serving as reservoirs, and multiple species with dual receptors that can act as mixing vessels enabling reassortment. ecent events in the United States, where H5N1 has emerged in dairy cattle with viral RNA detectable in retail milk and human cases arising from both poultry and dairy cattle exposures, further demonstrate the capacity of these viruses to invade new mammalian hosts and the food chain. Advances in poultry vaccination and next-generation antivirals show promise but are constrained by antigenic drift, incomplete protection, logistical barriers, and uneven uptake. Human preparedness remains weakened by diagnostic delays, limited access to therapeutics, and fragmented surveillance. Mitigation requires regionally tailored, One Health–driven strategies, market regulation, duck vaccination, swine surveillance, and rapid therapeutic deployment, together with equitable access to tools and transparent international collaboration to reduce zoonotic risk and strengthen global pandemic readiness. This review synthesizes recent evidence on avian influenza virus infections in Asia, outlining zoonotic risks, key drivers, and mitigation strategies, and concludes that the sustained circulation of these viruses in poultry and wild birds continues to present significant challenges for animal health, public health, and pandemic preparedness, highlighting the importance of strengthened One Health surveillance and control measures.
000169987 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000169987 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000169987 700__ $$aGrobusch, Martin P.
000169987 700__ $$aDrexler, Jan Felix
000169987 700__ $$0(orcid)0000-0002-9600-8116$$aPaño-Pardo, José Ramón$$uUniversidad de Zaragoza
000169987 700__ $$aPellejero-Sagastizabal, Galadriel$$uUniversidad de Zaragoza
000169987 700__ $$aTsiodras, Sotirios
000169987 700__ $$aBarac, Aleksandra
000169987 700__ $$aLescure, F.-Xavier
000169987 700__ $$aJokelainen, Pikka
000169987 700__ $$aBulescu, Casandra
000169987 700__ $$aGkrania-Klotsas, Effrossyni
000169987 700__ $$aMora-Rillo, Marta
000169987 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000169987 773__ $$g54, 1 (2025), 85-102$$pInfection$$tINFECTION$$x0300-8126
000169987 8564_ $$s881966$$uhttps://zaguan.unizar.es/record/169987/files/texto_completo.pdf$$yVersión publicada
000169987 8564_ $$s2587851$$uhttps://zaguan.unizar.es/record/169987/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000169987 909CO $$ooai:zaguan.unizar.es:169987$$particulos$$pdriver
000169987 951__ $$a2026-03-18-13:57:59
000169987 980__ $$aARTICLE