000170023 001__ 170023
000170023 005__ 20260316092629.0
000170023 0247_ $$2doi$$a10.1002/adma.202515863
000170023 0248_ $$2sideral$$a148511
000170023 037__ $$aART-2026-148511
000170023 041__ $$aeng
000170023 100__ $$aBraig, Johannes
000170023 245__ $$aFrom Fiber Architecture to Functional Attachment: A Clinically Relevant, Mechanically Tunable Cardiac Patch
000170023 260__ $$c2026
000170023 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170023 5203_ $$aContractile engineered cardiac patches hold great potential for treating myocardial infarction, serving as biological ventricular assist devices (BioVADs). However, optimal design and attachment of cardiac patches remain insufficiently explored, although both are essential for the mechanical support of damaged hearts. This study presents a platform for personalized macroscale patches with a multi‐zonal microarchitecture combining a regenerative zone for cell alignment, a stiff force transmission zone for load transfer, and an elastic attachment zone enabling integration. Based on computational modeling, the design is implemented using a custom G‐code generator for melt electrowriting (MEW). Digital image correlation reveals up to a 2.6‐fold strain difference between scaffold zones under physiological deformation, confirming zonal interplay. Biaxial testing with preconditioning shows scaffold mechanics replicating native myocardium properties up to 10% strain. For epicardial suture attachment, a reinforced outline enables shape‐morphing and increases suture retention 2.16‐fold. Dynamic BioVAD cultivation with fibrin‐embedded cardiomyocytes significantly (p = 0.01) improves cell alignment versus controls. Finally, in a porcine myocardial infarction model, the BioVAD achieves complete epicardial attachment and vascular ingrowth within 7 days, compared to partial attachment in controls. This study highlights MEW as a versatile platform for tailoring cardiac scaffold mechanics to support tissue integration and cardiac function.
000170023 536__ $$9info:eu-repo/grantAgreement/EC/H2020/874827/EU/Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts/BRAV3$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 874827-BRAV3$$9info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U13 Unit-CIBER-BBN
000170023 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170023 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170023 700__ $$aKent, Ross
000170023 700__ $$aGoienetxe, Ainitze Gereka
000170023 700__ $$0(orcid)0000-0001-8946-4829$$aLaita, Nicolás
000170023 700__ $$aWu, Ming
000170023 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, Miguel Ángel$$uUniversidad de Zaragoza
000170023 700__ $$aSerra, Margarida
000170023 700__ $$aJanssens, Koen
000170023 700__ $$aUrtaza, Uzuri
000170023 700__ $$aLarequi, Eduardo
000170023 700__ $$aAnaut-Lusar, Ilazki
000170023 700__ $$aGillijns, Hilde
000170023 700__ $$aAlgoet, Michiel
000170023 700__ $$avan Kerkhof, Britt
000170023 700__ $$avan der Knaap, Maite
000170023 700__ $$aCedillo-Servin, Gerardo
000170023 700__ $$aCastilho, Miguel
000170023 700__ $$avan Mil, Alain
000170023 700__ $$aSluijter, Joost P. G.
000170023 700__ $$aMalda, Jos
000170023 700__ $$aClaus, Piet
000170023 700__ $$aBovendeerd, Peter H. M.
000170023 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, Estefanía$$uUniversidad de Zaragoza
000170023 700__ $$0(orcid)0000-0001-8741-6452$$aDoblare, Manuel$$uUniversidad de Zaragoza
000170023 700__ $$aOosterlinck, Wouter
000170023 700__ $$aJanssens, Stefan
000170023 700__ $$aZaldua, Ane M.
000170023 700__ $$aIglesias-García, Olalla
000170023 700__ $$aPrósper, Felipe
000170023 700__ $$aVega, Manuel M. Mazo
000170023 700__ $$aGroll, Jürgen
000170023 700__ $$aJüngst, Tomasz
000170023 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000170023 773__ $$g(2026), e15863 [22 pp.]$$pAdv. mater.$$tAdvanced materials$$x0935-9648
000170023 8564_ $$s13939323$$uhttps://zaguan.unizar.es/record/170023/files/texto_completo.pdf$$yVersión publicada
000170023 8564_ $$s2626754$$uhttps://zaguan.unizar.es/record/170023/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170023 909CO $$ooai:zaguan.unizar.es:170023$$particulos$$pdriver
000170023 951__ $$a2026-03-16-08:17:00
000170023 980__ $$aARTICLE