170023 20260316092629.0 doi 10.1002/adma.202515863 sideral 148511 ART-2026-148511 eng Braig, Johannes From Fiber Architecture to Functional Attachment: A Clinically Relevant, Mechanically Tunable Cardiac Patch 2026 Contractile engineered cardiac patches hold great potential for treating myocardial infarction, serving as biological ventricular assist devices (BioVADs). However, optimal design and attachment of cardiac patches remain insufficiently explored, although both are essential for the mechanical support of damaged hearts. This study presents a platform for personalized macroscale patches with a multi‐zonal microarchitecture combining a regenerative zone for cell alignment, a stiff force transmission zone for load transfer, and an elastic attachment zone enabling integration. Based on computational modeling, the design is implemented using a custom G‐code generator for melt electrowriting (MEW). Digital image correlation reveals up to a 2.6‐fold strain difference between scaffold zones under physiological deformation, confirming zonal interplay. Biaxial testing with preconditioning shows scaffold mechanics replicating native myocardium properties up to 10% strain. For epicardial suture attachment, a reinforced outline enables shape‐morphing and increases suture retention 2.16‐fold. Dynamic BioVAD cultivation with fibrin‐embedded cardiomyocytes significantly (p = 0.01) improves cell alignment versus controls. Finally, in a porcine myocardial infarction model, the BioVAD achieves complete epicardial attachment and vascular ingrowth within 7 days, compared to partial attachment in controls. This study highlights MEW as a versatile platform for tailoring cardiac scaffold mechanics to support tissue integration and cardiac function. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/EC/H2020/874827/EU/Computational biomechanics and bioengineering 3D printing to develop a personalized regenerative biological ventricular assist device to provide lasting functional support to damaged hearts/BRAV3 This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 874827-BRAV3 info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-U13 Unit-CIBER-BBN info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Kent, Ross Goienetxe, Ainitze Gereka Laita, Nicolás (orcid)0000-0001-8946-4829 Wu, Ming Martínez, Miguel Ángel Universidad de Zaragoza (orcid)0000-0002-8375-0354 Serra, Margarida Janssens, Koen Urtaza, Uzuri Larequi, Eduardo Anaut-Lusar, Ilazki Gillijns, Hilde Algoet, Michiel van Kerkhof, Britt van der Knaap, Maite Cedillo-Servin, Gerardo Castilho, Miguel van Mil, Alain Sluijter, Joost P. G. Malda, Jos Claus, Piet Bovendeerd, Peter H. M. Peña, Estefanía Universidad de Zaragoza (orcid)0000-0002-0664-5024 Doblare, Manuel Universidad de Zaragoza (orcid)0000-0001-8741-6452 Oosterlinck, Wouter Janssens, Stefan Zaldua, Ane M. Iglesias-García, Olalla Prósper, Felipe Vega, Manuel M. Mazo Groll, Jürgen Jüngst, Tomasz 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. (2026), e15863 [22 pp.] Adv. mater. Advanced materials 0935-9648 13939323 http://zaguan.unizar.es/record/170023/files/texto_completo.pdf Versión publicada 2626754 http://zaguan.unizar.es/record/170023/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170023 articulos driver 2026-03-16-08:17:00 ARTICLE