Propagation of beta bursts from the motor cortex to the motor units of multiple upper-limb muscles

Graef, Cosima ; Pascual Valdunciel, Alejandro (Universidad de Zaragoza) ; Farina, Dario ; Vaidyanathan, Ravi ; Tai, Yen F ; Haar, Shlomi

Resumen: We provide the first evidence of cortical beta bursting in motor unit (MU) activity of forearm extensors across force levels. MU beta bursts are time-locked to cortical beta bursts, supporting direct corticospinal transmission in the upper limb. Our findings indicate that burst timing is robust to changes in contraction levels and demonstrate a robust cortical-peripheral beta relationship during isometric contractions. They also reinforce the utility of HDsEMG for investigating burst dynamics and refining neurophysiological biomarkers.

Idioma: Inglés

DOI: 10.1152/jn.00336.2025

Año: 2025

Publicado en: JOURNAL OF NEUROPHYSIOLOGY 135, 1 (2025), 97-109
ISSN: 0022-3077

Financiación: info:eu-repo/grantAgreement/EC/HORIZON EUROPE/101151398/EU/Implementation and validation of a closed-loop neural interface to entrain brain rhythms and reduce motor symptoms in Parkinson’s Disease

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)