000170064 001__ 170064
000170064 005__ 20260316092630.0
000170064 0247_ $$2doi$$a10.1007/s11259-026-11120-8
000170064 0248_ $$2sideral$$a148521
000170064 037__ $$aART-2026-148521
000170064 041__ $$aeng
000170064 100__ $$0(orcid)0000-0002-8727-0323$$aGonzález, Ana$$uUniversidad de Zaragoza
000170064 245__ $$aDetection of circulating immune complexes in feline leishmaniosis: first evidence and diagnostic implications
000170064 260__ $$c2026
000170064 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170064 5203_ $$aFeline leishmaniosis caused by Leishmania infantum is a zoonotic, vector-borne disease. While dogs are the main reservoir and exhibit immune-response–dependent spectra of illness, cats most often show lymphadenomegaly, dermatologic lesions, ocular or oral disease, weakness, weight loss, and clinicopathologic changes such as non-regenerative anemia, hyperglobulinemia, and proteinuria. Diagnosis benefits from combining serology and molecular tests, since single methods have limited clinical relevance. Circulating immune complexes drive many lesions in canine leishmaniosis and correlate with severity; a feline, Leishmania-specific circulating immune complexes assay has been lacking. This report describes an eight-year-old spayed European Shorthair cat from Spain with unilateral uveitis as the main clinical manifestation associated with Leishmania infantum infection. Leishmania infection was confirmed by positive immunochromatographic rapid test, high anti-Leishmania enzyme-linked immunosorbent assay and Western Blot reactivity, molecular test on blood and aqueous humor, and parasite culture with typing as L. infantum. A Leishmania-specific enzyme-linked immunosorbent assay adapted for detecting feline circulating immune complexes was developed and set up and the level of this promising biomarker was measured longitudinally during short-term follow-up. The cat received allopurinol (20 mg/kg every 24 h) plus topical anti-inflammatories. Clinical uveitis resolved within thirty days with concurrent improvements in activity and ocular findings. The kinetics of circulating immune complexes paralleled those of anti-Leishmania antibodies measured by enzyme-linked immunosorbent assay. This is the first clinical application of circulating immune complexes measure
in feline leishmaniosis. The isolation and detection of circulating immune complexes appear to be a useful biomarker for diagnosis, staging, and monitoring treatment response in cats.
000170064 536__ $$9info:eu-repo/grantAgreement/ES/DGA/AR15-32R
000170064 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170064 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170064 700__ $$aParody, Nuria
000170064 700__ $$aRenshaw, Ana
000170064 700__ $$aNavarro, Gemma
000170064 700__ $$aMontañés, Leticia
000170064 700__ $$0(orcid)0000-0001-5816-6167$$aLebrero, María Eugenia$$uUniversidad de Zaragoza
000170064 700__ $$0(orcid)0000-0001-6209-4282$$aVillanueva-Saz, Sergio$$uUniversidad de Zaragoza
000170064 700__ $$aFisa, Roser
000170064 700__ $$aMarteles-Aragüés, Diana$$uUniversidad de Zaragoza
000170064 700__ $$aRoca-Geronès, Xavier
000170064 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000170064 773__ $$g50, 3 (2026), [12 pp.]$$pVet. res. commun.$$tVeterinary Research Communications$$x0165-7380
000170064 8564_ $$s1342940$$uhttps://zaguan.unizar.es/record/170064/files/texto_completo.pdf$$yVersión publicada
000170064 8564_ $$s2124267$$uhttps://zaguan.unizar.es/record/170064/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170064 909CO $$ooai:zaguan.unizar.es:170064$$particulos$$pdriver
000170064 951__ $$a2026-03-16-08:17:56
000170064 980__ $$aARTICLE