000170071 001__ 170071
000170071 005__ 20260316092630.0
000170071 0247_ $$2doi$$a10.1021/acsbiomaterials.5c01488
000170071 0248_ $$2sideral$$a148607
000170071 037__ $$aART-2026-148607
000170071 041__ $$aeng
000170071 100__ $$aKulczynska, Julia
000170071 245__ $$aBiogenesis of Au Nanoparticles from Plant-Derived Metabolites – In Vitro and In Vivo StudiesClick to copy article link
000170071 260__ $$c2026
000170071 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170071 5203_ $$aBiomimetic gold nanoparticles (Au NPs) were synthesized via a sustainable approach without any additional toxic chemical reagents and fully characterized. It was proven that only whole aqueous extracts of Rosa damascene (RD) and Rosa rugosa (RR) are powerful enough to reduce, graft, and stabilize metallic nanostructures, resulting in the formation of stable, monodisperse nanocolloids (Au@RD NPs and Au@RR NPs) whereas individual constituent molecules were insufficient to yield stable metal NPs. The biological study conducted, both in vitro and in vivo, revealed no acute cytotoxicity (in HaCaT cell lines and zebrafish larval models) but bacteriostatic activity at equivalent doses with potent inhibition of biofilm formation (for a MRSA strain). Noteworthy, the additive antibacterial activity of rose extracts when combined with rifampicin promotes that these attractive inorganic–organic hybrids could be suitable alternatives to combat the acquisition of antimicrobial resistance. This huge application potential was also emphasized by the presence of insignificant changes in the expression of pro-inflammatory cytokine genes (IL-1β, IL-6, and CXCL8) and apoptotic/autophagic associated genes (TP53, MAP1LC3B, and SQSTM1) in treated HaCaT cells at antimicrobial doses. In addition, at the studied doses, the survival of Danio rerio larvae and their proper development (i.e., lack of deformities) endorsed biocompatibility in vivo.
000170071 536__ $$9info:eu-repo/grantAgreement/ES/AEI/CEX2023-001286-S$$9info:eu-repo/grantAgreement/ES/MICINN/PID2023-146091OB-I00
000170071 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000170071 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170071 700__ $$aTopa, Natalia
000170071 700__ $$aWidziolek, Magdalena
000170071 700__ $$aHoma, Joanna
000170071 700__ $$aKwiecien, Inga
000170071 700__ $$0(orcid)0000-0002-0272-3152$$aGamez, Enrique
000170071 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000170071 700__ $$aKyziol, Agnieszka
000170071 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000170071 773__ $$g12, 3 (2026), 1508-1521$$pACS biomater. sci. eng.$$tACS BIOMATERIALS SCIENCE & ENGINEERING$$x2373-9878
000170071 8564_ $$s9228922$$uhttps://zaguan.unizar.es/record/170071/files/texto_completo.pdf$$yVersión publicada
000170071 8564_ $$s3389248$$uhttps://zaguan.unizar.es/record/170071/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170071 909CO $$ooai:zaguan.unizar.es:170071$$particulos$$pdriver
000170071 951__ $$a2026-03-16-08:18:04
000170071 980__ $$aARTICLE