Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing

Li, Xuemei Schirra, Claudia Wirkner, Marie-Louise Tu, Szu-Min Lin, Chin-Hsin Hohmann, Meltem Gu, Yuan Santiago, Llipsy Pardo, Julian Arretxe, Iñaki Alawar, Nadia Chouaib, Abed Alrahman Becherer, Ute Lee, Po-Hsien Hsu, Hao-Jen Laschke, Matthias W. Baldari, Cosima T. Dustin, Michael L. Rettig, Jens Krause, Elmar Chang, Hsin-Fang Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing

Cell. mol. immunol.

10.1038/s41423-026-01391-1 2026

2026