170123 20260318155255.0 doi 10.1016/j.anpede.2021.04.008 sideral 148538 ART-2022-148538 eng Sánchez Malo, María José Growth hormone deficit: Influence of puberty on the response to treatment 2022 Introduction: Short stature is the most frequent reason for consultation in Pediatric Endocrinology consultations and sometimes requires treatment with growth hormone. The aim of the study was to analyze the response to treatment based on its onset in pubertal or prepubertal stages and to analyze the possible benefit of an early onset. Patients and methods: Longitudinal, retrospective and observational study in 139 patients treated for idiopathic growth hormone deficiency up to adult height. Main variables studied: (a) genetic background: maternal, paternal and genetic height; (b) perinatal history; (c) anthropometry during follow-up and at pubertal onset: weight, height, body mass index; (d) variables during follow-up and at pubertal onset: growth rate, bone age and growth prognosis. Final response variables: adult height, adult height with respect to target height, adult height with respect to initial growth prediction, adult height with respect to initial height at the start of treatment and adult height with respect to height at pubertal onset. Results: Total pubertal gain was 0.84 ± 0.6 SD. 61.9% of the patients started treatment with rhGH in prepuberty. The initiation of treatment in the prepubertal stage and a higher total pubertal gain are correlated with a better final height (P = 0.001 and r = 0.507, P = 0.00, respectively). Furthermore, a longer duration of treatment in pre-puberty is correlated with a better final response (r = 0.328, P = 0.00). Conclusions: The start of treatment in the prepubertal stage and its longer duration during this period are determining factors to achieve a good long-term response. Total pubertal gain was greater in patients who started treatment in the pubertal stage. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Hidalgo Sanz, Juan Hernández Tejedor, Cristina García Ventura, María Ferrer Lozano, Marta (orcid)0000-0002-5750-7350 Labarta Aizpún, Jose Ignacio Universidad de Zaragoza (orcid)0000-0003-2832-2266 de Arriba Muñoz, Antonio Universidad de Zaragoza (orcid)0000-0002-2865-5813 1011 670 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Pediatría 96, 3 (2022), 221-229 Anales de Pediatría (English Edition) 2341-2879 1172143 http://zaguan.unizar.es/record/170123/files/texto_completo.pdf Versión publicada 1814587 http://zaguan.unizar.es/record/170123/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170123 articulos driver 2026-03-18-13:52:46 ARTICLE