170125 20260318155255.0 doi 10.1016/j.rineng.2026.109764 sideral 148641 ART-2026-148641 eng Velarte, Antonio Universidad de Zaragoza (orcid)0000-0003-4361-6676 A modular soft core-based system for affordable acquisition and processing of electrophysiological recordings 2026 Flexible low-cost platforms for high-fidelity recording of biological signals are essential to advance health monitoring applications, yet they often rely on proprietary hardware that is resource-intensive and expensive. This study introduces a cost-effective FPGA platform that embeds an ARM Cortex M1 soft core processor with custom logic for signal acquisition, signal conditioning, artifact suppression, and data management, which is built around an Intan RHD2000 headstage. On-chip routines perform automatic offset calibration and gain calibration to ensure measurement fidelity. A graphical user interface, co-developed with biomedical end users, ensures compliance with data rate and timing constraints, enables live visualization, and streamlines parameter configuration. Bench validation using a multichannel test generator reproducing cardiac field potentials up to  ± 2 mV and bandwidths up to 5 kHz demonstrated stable timing, low crosstalk, and accurate amplitude reconstruction. Platform performance matches that of commercial multielectrode array systems, with minor deviations attributed to interconnection effects. Together, these results provide an accessible and extensible platform that preserves measurement fidelity while lowering the barrier to adoption in resource constrained laboratories. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/LMP 94-21 info:eu-repo/grantAgreement/ES/DGA/T23-23R info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00 info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Castel, Antonio (orcid)0009-0005-9285-2546 Otin, Aranzazu Universidad de Zaragoza (orcid)0000-0003-1403-1505 Olivan-Viguera, Aida (orcid)0000-0001-5348-924X Pueyo, Esther Universidad de Zaragoza (orcid)0000-0002-1960-407X 5008 785 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Tecnología Electrónica 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 29 (2026), 109764 [11 pp.] Results in Engineering 2590-1230 8328352 http://zaguan.unizar.es/record/170125/files/texto_completo.pdf Versión publicada 2742731 http://zaguan.unizar.es/record/170125/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170125 articulos driver 2026-03-18-13:52:49 ARTICLE