000170160 001__ 170160
000170160 005__ 20260407115448.0
000170160 0247_ $$2doi$$a10.1002/ueg2.70169
000170160 0248_ $$2sideral$$a148691
000170160 037__ $$aART-2026-148691
000170160 041__ $$aeng
000170160 100__ $$aCastells, Antoni
000170160 245__ $$aSex‐ and Age‐Stratified Outcomes of Colonoscopy Versus Faecal Immunochemical Testing: Post‐Analysis of the COLONPREV Study
000170160 260__ $$c2026
000170160 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170160 5203_ $$aBackground. Colorectal cancer (CRC) screening is effective and cost-effective in average-risk individuals. The COLONPREV study recently showed that individuals invited to a faecal immunochemical test (FIT) were more likely to participate in screening than those invited to colonoscopy, and that FIT-based screening was non-inferior to colonoscopy with respect to CRC-related mortality and CRC incidence.
Objective. To assess whether the outcomes of colonoscopy- and FIT-based screening differ according to sex and age in the invited population.
Methods. Presumptively healthy men and women aged 50–69 years were randomised to either a one-time screening colonoscopy or biennial FIT. In this analysis, we report participation and crossover rates, CRC-related mortality, CRC incidence, all-cause mortality, and diagnostic yield for both screening strategies, stratified by sex and by age group (50–59 and 60–69 years).
Results. The eligible population consisted of 26,332 individuals assigned to colonoscopy and 26,719 assigned to FIT. As expected, participation and crossover rates were higher in women than in men and in older individuals compared with younger individuals. Participation was also consistently higher in those invited to FIT screening than in those assigned to colonoscopy across both sexes and age groups. The observed reductions in CRC-related mortality and CRC incidence, which were consistent across both screening strategies, were independent of sex or age. However, CRC-related mortality, all-cause mortality, and CRC incidence remained higher in men and older participants than in women and younger participants. Colonoscopy screening showed a higher diagnostic yield of premalignant precursor lesions across all demographic subgroups.
Conclusion. Participation and reductions in CRC-related mortality and incidence were consistent across sex and age groups for both FIT- and colonoscopy-based screening strategies. The higher baseline risk observed in men could not be fully mitigated by screening.
Trial Registration. ClinicalTrials.gov: NCT00906997
000170160 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CD22-00087$$9info:eu-repo/grantAgreement/ES/ISCIII/FI22-00203$$9info:eu-repo/grantAgreement/ES/ISCIII/INT22-00009$$9info:eu-repo/grantAgreement/ES/ISCIII/PI08-90717
000170160 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000170160 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170160 700__ $$aQuintero, Enrique
000170160 700__ $$aSerra-Burriel, Miquel
000170160 700__ $$aBujanda, Luis
000170160 700__ $$aCastán-Cameo, Susana
000170160 700__ $$aCubiella, Joaquín
000170160 700__ $$aDíaz-Tasende, José
000170160 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Ángel$$uUniversidad de Zaragoza
000170160 700__ $$aOno, Akiko
000170160 700__ $$aColl-Vinent, Blanca
000170160 700__ $$aFrías-Arrocha, Eladio
000170160 700__ $$aHernández, Cristina
000170160 700__ $$aJover, Rodrigo
000170160 700__ $$aAndreu, Montserrat
000170160 700__ $$aCarballo, Fernando
000170160 700__ $$aMorillas, Juan Diego
000170160 700__ $$aSalas, Dolores
000170160 700__ $$a
000170160 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000170160 773__ $$g14, 2 (2026), e70169 [9 pp.]$$pUnited European Gastroenterol. j.$$tUnited European Gastroenterology Journal$$x2050-6406
000170160 8564_ $$s1141996$$uhttps://zaguan.unizar.es/record/170160/files/texto_completo.pdf$$yVersión publicada
000170160 8564_ $$s2563729$$uhttps://zaguan.unizar.es/record/170160/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000170160 951__ $$a2026-03-26-14:30:46
000170160 980__ $$aARTICLE