170177 20260407115449.0 doi 10.3390/ijms27031309 sideral 148715 ART-2026-148715 eng Serrano-Casorrán, Carolina Universidad de Zaragoza (orcid)0000-0002-8880-6580 The local damage and systemic inflammation induced by a biodegradable polydioxanone Stent implanted in the rabbit trachea decreases markedly with Stent degradation 2026 Biodegradable tracheal stents have been developed to overcome the limitations of metallic and removable stents in benign airway disease. This study evaluated the local and systemic inflammatory response induced by a biodegradable polydioxanone tracheal stent in a rabbit model. Twenty-one rabbits were assigned to three follow-up groups (30, 60, and 90 days). In each group, six animals received a tracheal stent, and one served as a sham control. Clinical status and respiratory symptoms were monitored, and serial peripheral blood interleukin-8 (IL-8) levels were measured. At the end of follow-up, tracheoscopy, IL-8 quantification in tracheal lavage, and necropsy were performed. No deaths or severe respiratory symptoms occurred. Tracheoscopic findings were significantly less severe after stent degradation, with reduced congestion (p = 0.030), inflammation (p = 0.003), and secretions (p = 0.030). Two granulomas and two cases of stenosis were identified. Mean IL-8 expression in tracheal lavage (relative quantification, RQ) was 14,129 ± 3007 when the stent was present and 426 ± 100 after degradation (p = 0.003). Blood IL-8 expression increased significantly on day 1 compared with baseline (p = 0.022) and subsequently decreased (p = 0.034). Inflammatory and structural alterations induced by a polydioxanone tracheal stent decrease after stent degradation. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/B36-23R info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rodríguez-Zapater, Sergio (orcid)0000-0003-3880-3821 Rodríguez-Panadero, Francisco Gómez, Raquel Bonastre, Cristina Universidad de Zaragoza (orcid)0000-0001-6178-9891 Guirola, José Andrés Universidad de Zaragoza (orcid)0000-0002-0113-5121 Rodríguez, José Universidad de Zaragoza (orcid)0000-0001-9605-4959 Gregorio, Miguel Ángel de Universidad de Zaragoza (orcid)0000-0002-5618-7519 1011 770 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Radiol. y Medicina Física 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 27, 3 (2026), 1309 [12 pp.] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 1980684 http://zaguan.unizar.es/record/170177/files/texto_completo.pdf Versión publicada 2369874 http://zaguan.unizar.es/record/170177/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170177 articulos driver 2026-03-26-14:31:06 ARTICLE