000170208 001__ 170208
000170208 005__ 20260407115449.0
000170208 0247_ $$2doi$$a10.3390/jcm15041360
000170208 0248_ $$2sideral$$a148689
000170208 037__ $$aART-2026-148689
000170208 041__ $$aeng
000170208 100__ $$aRecio-Ibarz, Mario J.
000170208 245__ $$aPremature Ventricular Complex-Induced Cardiomyopathy, a Review: Current Insights, Diagnostic Challenges, and Therapeutic Strategies
000170208 260__ $$c2026
000170208 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170208 5203_ $$aPremature Ventricular Complexes (PVCs) are among the most frequent ventricular arrhythmias observed in daily cardiology practice. Although often benign, sustained high ectopic activity can result in left ventricular dysfunction known as PVC-induced Cardiomyopathy (PVC-CMP), a condition that is frequently reversible when the arrhythmia is effectively suppressed. The underlying mechanisms are multifaceted, involving electromechanical dyssynchrony, contractile inefficiency, abnormal calcium cycling, neurohormonal activation, and progressive structural remodeling. The likelihood of developing PVC-CMP varies among individuals and is influenced by electrophysiological and structural factors. Diagnosis relies on prolonged rhythm monitoring, comprehensive multimodality imaging, and demonstration of ventricular recovery after reducing the ectopic burden, which, in turn, confirms causality. Over the past decade, major advances in electrocardiographic mapping, cardiac imaging, and ablation therapy have transformed this field, demonstrating excellent efficacy and safety profiles. In parallel, artificial intelligence and computational mapping are emerging as powerful tools for prediction and procedural guidance. Recognition of PVC-CMP as a distinct, treatable cardiomyopathy highlights the importance of early detection and individualized therapy, offering the prospect of complete functional recovery and the prevention of heart failure progression.
000170208 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170208 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170208 700__ $$aOlóriz, Teresa
000170208 700__ $$0(orcid)0000-0002-1889-3746$$aCalvo, Naiara$$uUniversidad de Zaragoza
000170208 700__ $$0(orcid)0000-0001-9187-1773$$aJáuregui, Beatriz$$uUniversidad de Zaragoza
000170208 700__ $$0(orcid)0000-0001-7431-0376$$aAlonso-Ventura, Vanesa$$uUniversidad de Zaragoza
000170208 700__ $$0(orcid)0000-0002-4606-4347$$aCantero Lozano, Daniel
000170208 700__ $$aLópez-Perales, Carlos
000170208 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000170208 773__ $$g15, 4 (2026), 1360$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000170208 8564_ $$s2560950$$uhttps://zaguan.unizar.es/record/170208/files/texto_completo.pdf$$yVersión publicada
000170208 8564_ $$s2448966$$uhttps://zaguan.unizar.es/record/170208/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170208 909CO $$ooai:zaguan.unizar.es:170208$$particulos$$pdriver
000170208 951__ $$a2026-03-26-14:31:43
000170208 980__ $$aARTICLE