000170232 001__ 170232
000170232 005__ 20260407115449.0
000170232 0247_ $$2doi$$a10.1371/journal.pcbi.1013688
000170232 0248_ $$2sideral$$a148722
000170232 037__ $$aART-2026-148722
000170232 041__ $$aeng
000170232 100__ $$aRosales, Ricardo M.
000170232 245__ $$aIntegrated multi-modal data analysis for computational modeling of healthy and location-dependent myocardial infarction conditions in porcine hearts
000170232 260__ $$c2026
000170232 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170232 5203_ $$aPorcine hearts are widely used for preclinical cardiac evaluation. Computational models, by effectively integrating comprehensive experimental data, often reinforce this preclinical assessment. Using extensive multi-modal data, we developed swine ventricular digital twins for healthy and chronic myocardial infarction (MI) conditions to investigate the roles of the cardiac conduction system (CS), spatial repolarization heterogeneities, cardiomyocyte orientation, cell-to-cell coupling, and MI characteristics on ventricular function. We analyzed cardiac magnetic resonance (CMR) images, electrocardiograms (ECGs), and optical (OM) and electroanatomical mapping from 5 healthy and 10 MI pigs. CS architectures were built from OM and ECG recordings. Myocardial fiber orientation, action potential characteristics, and cell-to-cell conductivity in MI tissue were defined from OM and CMR data. Simulated ECGs for healthy and MI models of left anterior descending and left circumflex occlusions were compared to experimental ECGs and were used to assess MI-induced changes. Subject-specific fiber orientation calibration minimally affected electrophysiology, with conduction velocity (CV) and action potential duration (APD) changing by less than 3.6% with respect to standard orientation. Accurate CS and repolarization heterogeneities reproduced depolarization (Pearson correlation 0.76 for QRS) and repolarization (Pearson correlation 0.74 for T-wave) patterns. Incorporating experimentally guided MI-induced alterations enabled the replication of MI depolarization and repolarization features (relative errors: 0.5% CV, 2.9% APD), yielded realistic T-wave morphologies (0.63 Pearson correlation), and revealed ECG patterns specific to vessel-dependent occlusions. Thus, by integrating extensive multi-modal data, we advance porcine cardiac digital twins and demonstrate the influence of key structural and electrophysiological parameters on healthy and MI heart function, providing a robust computational framework for mechanistic and translational applications.
000170232 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2023-148975OB-I00$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-23R-BSICoS$$9info:eu-repo/grantAgreement/ES/MCIN/PLEC2021-008127$$9info:eu-repo/grantAgreement/ES/MICINN/CNS2022-135899$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-140556OB-I00$$9info:eu-repo/grantAgreement/EUR/MICINN/TED2021-130459B-I00
000170232 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170232 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170232 700__ $$aWu, Ming
000170232 700__ $$aClaus, Piet
000170232 700__ $$aJanssens, Stefan
000170232 700__ $$aRíos-Muñoz, Gonzalo R.
000170232 700__ $$aFernández-Santos, María Eugenia
000170232 700__ $$aMartínez-Legazpi, Pablo
000170232 700__ $$aBermejo, Javier
000170232 700__ $$aFlanagan, Aiden
000170232 700__ $$0(orcid)0000-0001-8741-6452$$aDoblaré, Manuel$$uUniversidad de Zaragoza
000170232 700__ $$0(orcid)0000-0003-3183-4107$$aMincholé, Ana$$uUniversidad de Zaragoza
000170232 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000170232 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000170232 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000170232 773__ $$g22, 3 (2026), e1013688 [38 pp.]$$pPLoS Comput. Biol.$$tPLOS COMPUTATIONAL BIOLOGY$$x1553-734X
000170232 8564_ $$s3975531$$uhttps://zaguan.unizar.es/record/170232/files/texto_completo.pdf$$yVersión publicada
000170232 8564_ $$s2876380$$uhttps://zaguan.unizar.es/record/170232/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170232 909CO $$ooai:zaguan.unizar.es:170232$$particulos$$pdriver
000170232 951__ $$a2026-03-26-14:32:13
000170232 980__ $$aARTICLE