170273 20260410165451.0 doi 10.1111/head.70086 sideral 148819 ART-2026-148819 eng García-Castillo, María Clara Evaluation of the effectiveness and safety of anti-CGRPmonoclonal antibodies in patients with migraine andautoimmune diseases: IMMUNO-CGRP study 2026 Objective: This study aimed to evaluate demographic characteristics, treatment effectiveness, and safety outcomes in patients with migraine undergoing anti‐calcitonin gene‐related peptide (CGRP) treatments regarding the presence of autoimmune diseases. Background: CGRP has an important role in migraine pathophysiology through neuronal modulation in the trigeminovascular nociceptive system and activation of neuro‐inflammatory cascades. We hypothesized that autoimmune diseases may influence treatment response and safety profiles in patients with migraine treated with anti‐CGRP treatments. Methods: This was a retrospective multicenter, age‐ and sex‐matched cohort study in headache units/headache clinics in Spain and United Kingdom between May 2024 and May 2025 including patients treated with CGRP monoclonal antibodies from prospectively collected cohorts. Patients were assessed for demographics, migraine‐related characteristics, treatment effectiveness (monthly migraine days [MMD] and/or monthly headache days [MHD]), and safety outcomes. The main outcome was the effectiveness measured by ≥50% response rate in MMD between the two groups. Secondary outcomes included other effectiveness measurements regarding the number of MMD and MHD and treatment emerging adverse events. Results: A total of 388 patients with migraine under anti‐CGRP treatments (194 with autoimmune diseases and 194 age‐ and sex‐matched controls without autoimmune diseases) were included. The proportion of patients achieving a ≥50% response rate in MMD was higher in patients without autoimmune diseases at 6 (69% vs. 53%; p = 0.006) and 9 months (74% vs. 52%; p = 0.006). Treatment emerging adverse events were comparable between the two groups (35% vs. 38%; p = 0.575). Patients with autoimmune disease had a significantly lower likelihood of achieving a ≥50% response in MMD compared with those without autoimmune disease (adjusted odds ratio, 0.61; 95% confidence interval, 0.44–0.85; p = 0.006), independent of comorbid depression and medication overuse. Conclusions: Our study shows that anti‐CGRP treatments are effective and safe for patients with migraine regardless the presence of autoimmune diseases, although an increased treatment response in patient without autoimmune disorders compared to patients with autoimmune disorders was observed. These findings highlight the need for early intervention, tailored strategies, and vigilant monitoring in patients with migraine and autoimmune disorders. Further research should explore immunomodulatory approaches to enhance outcomes. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/ISCIII/CM21-00178 info:eu-repo/grantAgreement/ES/ISCIII/PI24-01085 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Sierra-Mencía, Álvaro Caronna, Edoardo Toledo-Alfocea, Daniel Jaimes, Alex Urtiaga, Sarai Casas-Limón, Javier Muñoz-Vendrell, Albert Santos-Lasaosa, Sonia Universidad de Zaragoza (orcid)0000-0001-5139-6031 García Martín, Valvanuz Martín Ávila, Guillermo Polanco, Marcos Villar-Martínez, Maria Dolores Trevino-Peinado, Cristina Rubio-Flores, Laura Sánchez-Soblechero, Antonio Portocarrero Sánchez, Leonardo Luque-Buzo, Elisa Lozano-Ros, Alberto Gago-Veiga, Ana Beatriz Díaz-De-Terán, Javier Recio García, Andrea Canales Rodríguez, Javiera Gómez García, Andrea González Salaices, Marta Campoy, Sergio Mínguez-Olaondo, Ane Maniataki, Stefania González-Quintanilla, Vicente Porta-Etessam, Jesús Cuadrado, María-Luz Guerrero Peral, Ángel Luis Pozo-Rosich, Patricia Rodríguez-Vico, Jaime Huerta-Villanueva, Mariano Pascual, Julio Goadsby, Peter J. Gonzalez-Martinez, Alicia 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina (2026), [12 pp.] Headache Headache 0017-8748 770768 http://zaguan.unizar.es/record/170273/files/texto_completo.pdf Versión publicada 2237865 http://zaguan.unizar.es/record/170273/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170273 articulos driver 2026-04-10-13:45:38 ARTICLE