000170274 001__ 170274
000170274 005__ 20260410165451.0
000170274 0247_ $$2doi$$a10.1016/j.ejrad.2026.112818
000170274 0248_ $$2sideral$$a148787
000170274 037__ $$aART-2026-148787
000170274 041__ $$aeng
000170274 100__ $$aUrbano, J.
000170274 245__ $$aEthylene-vinyl alcohol copolymer: Histopathological findings after pre-surgical right portal vein embolisation
000170274 260__ $$c2026
000170274 5203_ $$aPurpose
To describe the gross and microscopic histopathological changes observed in human liver tissue resected after pre-surgical portal vein embolization (PVE) performed exclusively with ethylene–vinyl alcohol copolymer (EVOH)
Materials and methods
This retrospectively study reviewed 12 consecutive patients who underwent right PVE with EVOH as the sole embolic before right hemi-hepatectomy. Demographics, peri-procedural data, and future liver remnant (FLR) volumetry were collected. Gross and microscopic examinations were performed on liver parenchyma from resected specimens using hematoxylin-eosin (H&E) and Masson’s trichrome stains. The distribution of EVOH within the portal venous tree and parenchymal changes were assessed.
Results
All patients achieved liver hypertrophy and underwent right hepatectomy 4–8 weeks after PVE. Mean pre-PVE FLR was 21.3% ± 4.8. Mean post-PVE FLR was 35.6% ± 5.5. There was no unwanted migration of EVOH into left portal vein. There were no EVOH-related complications. EVOH completely occluded targeted macro- and micro-portal branches without recanalization. The material reached portal venules within the portal triads in all cases and, in two cases, was also identified within sinusoids/centrilobular veins without associated inflammatory reaction. Histology showed a foreign-body type response with multinucleated giant cells and mild perivascular fibrosis confined to occluded portal veins. There was no acute inflammation, hepatocellular necrosis, or cholangiolar injury.
Conclusion
EVOH penetrates deeply into the macro and microscopic branches of the portal vein. It produces effective short-term occlusion with limited, localized foreign-body reaction and no evidence of hepatocellular injury. It facilitates adequate FLR hypertrophy and subsequent right hepatectomy.
000170274 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000170274 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170274 700__ $$0(orcid)0000-0002-3158-7022$$aLostalé, F.
000170274 700__ $$aRomera, R.
000170274 700__ $$aTorres, L.
000170274 700__ $$0(orcid)0000-0002-0113-5121$$aGuirola, A.$$uUniversidad de Zaragoza
000170274 700__ $$0(orcid)0000-0002-5618-7519$$ade Gregorio, M.A.$$uUniversidad de Zaragoza
000170274 7102_ $$11011$$2770$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Radiol. y Medicina Física
000170274 773__ $$g199 (2026), 112818 [6 p.]$$pEur. j. radiol.$$tEuropean Journal of Radiology$$x0720-048X
000170274 8564_ $$s8316151$$uhttps://zaguan.unizar.es/record/170274/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2027-04-02
000170274 8564_ $$s2236244$$uhttps://zaguan.unizar.es/record/170274/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2027-04-02
000170274 909CO $$ooai:zaguan.unizar.es:170274$$particulos$$pdriver
000170274 951__ $$a2026-04-10-13:45:39
000170274 980__ $$aARTICLE