170280 20260410165451.0 doi 10.1021/acssuschemeng.6c00237 sideral 148849 ART-2026-148849 eng Clemente, Alberto Universidad de Zaragoza Biobased Functional Ionic Liquids for a Novel Approach to Sonogashira Coupling in the Absence of Copper and External Bases 2026 We report the first use of functional renewable ionic liquids, with favorable ecotoxicological profiles toward representative microorganisms, in efficient and recoverable nanoparticle-based catalytic systems to promote copper-free Sonogashira coupling reactions in the absence of externally added bases. These systems, based on palladium nanoparticles immobilized on glycerol-derived [N201]X ionic liquids bearing basic anions, achieved the coupling of differently substituted substrates in 1 h. Contrarily, analogous ionic liquids without basic character and classic imidazolium ionic liquids ─[BMIm]PF6─ were not active for the test reaction at all, even if a large excess of an external base was added. Different product selectivities were observed, as a function of the different hydrophilic nature (and water content) of the ionic liquid. Therefore, this novel approach improves the catalytic results under milder conditions and minimizes waste generation, as observed in the green metrics determined for the benchmark process, offering a more sustainable and effective alternative in cross-coupling transformations. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/AEI/AEI PID2021-125762NB-I00 info:eu-repo/grantAgreement/ES/DGA/E37-23R info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cambronero-Arregui, Jorge Aínsa, José A. Universidad de Zaragoza (orcid)0000-0003-2076-844X Pires, Elísabet Universidad de Zaragoza (orcid)0000-0002-2676-8814 Mayoral, José A. Universidad de Zaragoza (orcid)0000-0003-1570-4257 Leal-Duaso, Alejandro (orcid)0000-0002-3256-2089 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica (2026), [7 pp.] ACS sustain. chem. & eng. ACS Sustainable Chemistry and Engineering 2168-0485 1961913 http://zaguan.unizar.es/record/170280/files/texto_completo.pdf Versión publicada 3149065 http://zaguan.unizar.es/record/170280/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170280 articulos driver 2026-04-10-13:45:45 ARTICLE