000170398 001__ 170398
000170398 005__ 20260422084205.0
000170398 0247_ $$2doi$$a10.1002/anie.8446184
000170398 0248_ $$2sideral$$a148895
000170398 037__ $$aART-2026-148895
000170398 041__ $$aeng
000170398 100__ $$aZahid, Rabia
000170398 245__ $$aStimuli‐responsive silsesquioxane nanozymes for organocatalysis in water and prodrug activation in cells
000170398 260__ $$c2026
000170398 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170398 5203_ $$aSynthetic nanozymes have emerged as promising alternatives to natural enzymes for catalytic and therapeutic applications, yet their limited stability, aqueous compatibility, and catalytic scope impede broader utilization. Here, we report a mild, one‐step sol–gel synthesis that yields ultrasmall, water‐stable octa‐amino silsesquioxanes functioning as metal‐free nanozymes. These minimalistic nanostructures exhibit aldolase‐like organocatalytic activity in water and enable dynamic, stimuli‐responsive modulation of catalysis through reversible supramolecular aggregation and disaggregation triggered by specific chemical inputs, thus forming a multifunctional platform for tunable catalysis and biomedical applications. Structural simplicity, stability, and functional versatility together permit tunable, enzyme‐like catalysis in water without auxiliary surfactants or phase‐transfer additives. Furthermore, the nanozymes display high biocompatibility and efficient cellular internalization, enabling their use in living cells, for instance, as intracellular prodrug activators via retro‐aldol activation of a doxorubicin prodrug in human glioblastoma and metastatic melanoma cells, resulting in selective cytotoxicity. This system provides a cost‐effective, sustainable, and scalable platform for water‐compatible, metal‐free organocatalysis that bridges abiotic catalysis and biological function. These findings demonstrate how rationally designed silsesquioxane frameworks can emulate natural enzyme reactivity while integrating adaptive, stimuli‐responsive behavior, broadening the applicability of synthetic nanozymes to catalytic and therapeutic contexts.
000170398 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2023-148732NB-I00$$9info:eu-repo/grantAgreement/EUR/COST/CA22131-LUCES$$9info:eu-repo/grantAgreement/ES/MICIU/RYC2024-050017-I
000170398 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170398 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170398 700__ $$aLázaro, Ariadna
000170398 700__ $$aMoreno-Alcántar, Guillermo
000170398 700__ $$0(orcid)0000-0001-8762-5457$$aSancho-Albero, María$$uUniversidad de Zaragoza
000170398 700__ $$aPicchetti, Pierre
000170398 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000170398 773__ $$g(2026), e8446184 [11 pp.]$$pAngew. Chem. (Int. ed.)$$tAngewandte Chemie (International ed.)$$x1433-7851
000170398 8564_ $$s2423820$$uhttps://zaguan.unizar.es/record/170398/files/texto_completo.pdf$$yVersión publicada
000170398 8564_ $$s2438879$$uhttps://zaguan.unizar.es/record/170398/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170398 909CO $$ooai:zaguan.unizar.es:170398$$particulos$$pdriver
000170398 951__ $$a2026-04-22-08:40:09
000170398 980__ $$aARTICLE