000170418 001__ 170418
000170418 005__ 20260420103355.0
000170418 0247_ $$2doi$$a10.1002/adhm.202505120
000170418 0248_ $$2sideral$$a148863
000170418 037__ $$aART-2026-148863
000170418 041__ $$aeng
000170418 100__ $$0(orcid)0000-0003-3661-7718$$aGuerrero-López, Paula$$uUniversidad de Zaragoza
000170418 245__ $$aCopper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids
000170418 260__ $$c2026
000170418 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170418 5203_ $$aCopper is a key trace element with established cytotoxic properties, yet its interactions with the extracellular matrix and their implications for the evolution of 3D culture models remain poorly understood. Here, we study how copper entrapped in collagen can regulate the structural and invasive properties of 3D tumor spheroids. Our findings reveal that copper influences cytoskeletal organization, protrusion dynamics, and epithelial–mesenchymal transitions. Interestingly, we also highlight its dual capacity to either suppress or enhance invasive behavior depending on the context of exposure. These results position copper as a context‐dependent modulator of tumor progression and underscore the importance of dose and timing in determining therapeutic outcomes. By integrating a physiologically relevant 3D model, this study provides new insights into copper–ECM interactions and identifies potential strategies to exploit them for cancer therapy.
000170418 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2023-148732NB-I00$$9info:eu-repo/grantAgreement/ES/DGA/T50-23R$$9info:eu-repo/grantAgreement/ES/UZ-DGA/T57-23R$$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE$$9info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S
000170418 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170418 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170418 700__ $$0(orcid)0000-0003-4874-6672$$aGarcia-Peiro, Jose I.$$uUniversidad de Zaragoza
000170418 700__ $$aHornos, Felipe
000170418 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, Jose L.$$uUniversidad de Zaragoza
000170418 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, Jesus$$uUniversidad de Zaragoza
000170418 700__ $$0(orcid)0000-0002-9864-7683$$aGarcia-Aznar, J. Manuel$$uUniversidad de Zaragoza
000170418 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000170418 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física
000170418 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000170418 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000170418 773__ $$g(2026), e05120 [12 pp.]$$pAdvanced healthcare materials$$tADVANCED HEALTHCARE MATERIALS$$x2192-2640
000170418 8564_ $$s1951715$$uhttps://zaguan.unizar.es/record/170418/files/texto_completo.pdf$$yVersión publicada
000170418 8564_ $$s2351631$$uhttps://zaguan.unizar.es/record/170418/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170418 909CO $$ooai:zaguan.unizar.es:170418$$particulos$$pdriver
000170418 951__ $$a2026-04-18-10:49:12
000170418 980__ $$aARTICLE