000170439 001__ 170439
000170439 005__ 20260420103355.0
000170439 0247_ $$2doi$$a10.1016/j.jcat.2026.116860
000170439 0248_ $$2sideral$$a148918
000170439 037__ $$aART-2026-148918
000170439 041__ $$aeng
000170439 100__ $$aCambronero-Arregui, Jorge
000170439 245__ $$aOne-pot stepwise and consecutive mechanistically incompatible solvent-free reactions: Synthetic and mechanistic insights
000170439 260__ $$c2026
000170439 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170439 5203_ $$aPd nanoparticles supported on an accessible laponite clay are efficient and highly recoverable catalytic systems in benchmark coupling and hydrogenation reactions under solvent-free conditions. In this paper, we explore the use of these supported catalytic systems in one-pot stepwise and consecutive reactions with excellent isolated yields. Whereas the catalyst recovered from hydrogenation reactions remains active in both coupling and hydrogenation processes, the catalyst used in coupling reactions is progressively deactivated for further hydrogenations. This behavior is not due neither to the nanoparticles agglomeration nor to Pd leaching, but to the formation of Pd(II) on the catalyst surface, disclosing a clear XPS evidence for the theory of the “release and capture” mechanism. Nonetheless, the hydrogenation activity is fully recovered after reducing this surface Pd(II) using ethanol. Finally, we have applied this strategy in the synthesis of products with practical pharmaceutical interest such as nabumetone and resveratrol.
000170439 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E37-23R$$9info:eu-repo/grantAgreement/ES/MINECO/PID2021-125762NB-I00
000170439 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es
000170439 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170439 700__ $$aMartínez, Alejandro V.
000170439 700__ $$0(orcid)0000-0002-2676-8814$$aPires, Elisabet$$uUniversidad de Zaragoza
000170439 700__ $$0(orcid)0000-0003-1570-4257$$aMayoral, José A.$$uUniversidad de Zaragoza
000170439 700__ $$0(orcid)0000-0002-3256-2089$$aLeal-Duaso, Alejandro
000170439 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000170439 773__ $$g458 (2026), 116860 [11 pp.]$$pJ. catal.$$tJournal of Catalysis$$x0021-9517
000170439 8564_ $$s5711347$$uhttps://zaguan.unizar.es/record/170439/files/texto_completo.pdf$$yVersión publicada
000170439 8564_ $$s2596699$$uhttps://zaguan.unizar.es/record/170439/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170439 909CO $$ooai:zaguan.unizar.es:170439$$particulos$$pdriver
000170439 951__ $$a2026-04-18-10:49:35
000170439 980__ $$aARTICLE