170439 20260420103355.0 doi 10.1016/j.jcat.2026.116860 sideral 148918 ART-2026-148918 eng Cambronero-Arregui, Jorge One-pot stepwise and consecutive mechanistically incompatible solvent-free reactions: Synthetic and mechanistic insights 2026 Pd nanoparticles supported on an accessible laponite clay are efficient and highly recoverable catalytic systems in benchmark coupling and hydrogenation reactions under solvent-free conditions. In this paper, we explore the use of these supported catalytic systems in one-pot stepwise and consecutive reactions with excellent isolated yields. Whereas the catalyst recovered from hydrogenation reactions remains active in both coupling and hydrogenation processes, the catalyst used in coupling reactions is progressively deactivated for further hydrogenations. This behavior is not due neither to the nanoparticles agglomeration nor to Pd leaching, but to the formation of Pd(II) on the catalyst surface, disclosing a clear XPS evidence for the theory of the “release and capture” mechanism. Nonetheless, the hydrogenation activity is fully recovered after reducing this surface Pd(II) using ethanol. Finally, we have applied this strategy in the synthesis of products with practical pharmaceutical interest such as nabumetone and resveratrol. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/DGA/E37-23R info:eu-repo/grantAgreement/ES/MINECO/PID2021-125762NB-I00 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Martínez, Alejandro V. Pires, Elisabet Universidad de Zaragoza (orcid)0000-0002-2676-8814 Mayoral, José A. Universidad de Zaragoza (orcid)0000-0003-1570-4257 Leal-Duaso, Alejandro (orcid)0000-0002-3256-2089 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 458 (2026), 116860 [11 pp.] J. catal. Journal of Catalysis 0021-9517 5711347 http://zaguan.unizar.es/record/170439/files/texto_completo.pdf Versión publicada 2596699 http://zaguan.unizar.es/record/170439/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170439 articulos driver 2026-04-18-10:49:35 ARTICLE