000170449 001__ 170449 000170449 005__ 20260420103355.0 000170449 0247_ $$2doi$$a10.1002/adfm.202600051 000170449 0248_ $$2sideral$$a148948 000170449 037__ $$aART-2026-148948 000170449 041__ $$aeng 000170449 100__ $$aEncinas-Gimenez, Miguel 000170449 245__ $$aUltrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy 000170449 260__ $$c2026 000170449 5060_ $$aAccess copy available to the general public$$fUnrestricted 000170449 5203_ $$aDespite decades of intense research, cancer remains a major global health challenge, with a clear need for new and more efficient therapies. Among emerging approaches, high atomic number (Z) nanomaterials capable of modulating the interaction between radiation and matter have attracted growing interest as radiotherapy enhancers. In this work, ultra‐small Platinum‐based nanoparticles with a metallic core diameter of 2–3 nm were synthesized from H2PtCl6 using polyvinylpyrrolidone as stabilizer. This nanomaterial exhibits low acute toxicity, catalase‐like activity and enhances DNA damage under pre‐clinical X‐ray irradiation, increasing the antitumoral effect of X‐ray alone. In vitro and in vivo studies, including intratumoral and intravenous administration, demonstrate improved tumor control and prolonged survival without detectable systemic toxicity under the tested conditions, establishing ultra‐small Pt‐nanoparticles as efficient materials for radiotherapy enhancement. 000170449 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2023-148732NB-I00$$9info:eu-repo/grantAgreement/ES/UZ-DGA/T57-23R$$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/CIBER-BBN$$9info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S 000170449 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000170449 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000170449 700__ $$0(orcid)0000-0003-4874-6672$$aGarcia-Peiro, Jose I.$$uUniversidad de Zaragoza 000170449 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, Jose L.$$uUniversidad de Zaragoza 000170449 700__ $$aCaleiras, Eduardo 000170449 700__ $$aNotario, Laura 000170449 700__ $$aHornos, Felipe 000170449 700__ $$aMartin-Duque, Pilar 000170449 700__ $$aDe la Vieja, Antonio 000170449 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, Jesus$$uUniversidad de Zaragoza 000170449 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química 000170449 7102_ $$12012$$2755$$aUniversidad de Zaragoza$$bDpto. Química Física$$cÁrea Química Física 000170449 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente 000170449 773__ $$g(2026), e00051 [24 pp.]$$pAdv. funct. mater.$$tAdvanced Functional Materials$$x1616-301X 000170449 8564_ $$s5533584$$uhttps://zaguan.unizar.es/record/170449/files/texto_completo.pdf$$yVersión publicada 000170449 8564_ $$s2487965$$uhttps://zaguan.unizar.es/record/170449/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000170449 909CO $$ooai:zaguan.unizar.es:170449$$particulos$$pdriver 000170449 951__ $$a2026-04-18-10:49:47 000170449 980__ $$aARTICLE