170449 20260420103355.0 doi 10.1002/adfm.202600051 sideral 148948 ART-2026-148948 eng Encinas-Gimenez, Miguel Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy 2026 Despite decades of intense research, cancer remains a major global health challenge, with a clear need for new and more efficient therapies. Among emerging approaches, high atomic number (Z) nanomaterials capable of modulating the interaction between radiation and matter have attracted growing interest as radiotherapy enhancers. In this work, ultra‐small Platinum‐based nanoparticles with a metallic core diameter of 2–3 nm were synthesized from H2PtCl6 using polyvinylpyrrolidone as stabilizer. This nanomaterial exhibits low acute toxicity, catalase‐like activity and enhances DNA damage under pre‐clinical X‐ray irradiation, increasing the antitumoral effect of X‐ray alone. In vitro and in vivo studies, including intratumoral and intravenous administration, demonstrate improved tumor control and prolonged survival without detectable systemic toxicity under the tested conditions, establishing ultra‐small Pt‐nanoparticles as efficient materials for radiotherapy enhancement. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/AEI/PID2023-148732NB-I00 info:eu-repo/grantAgreement/ES/UZ-DGA/T57-23R info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE info:eu-repo/grantAgreement/ES/ISCIII-FEDER/CIBER-BBN info:eu-repo/grantAgreement/ES/MICIU/CEX2023-001286-S info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Garcia-Peiro, Jose I. Universidad de Zaragoza (orcid)0000-0003-4874-6672 Hueso, Jose L. Universidad de Zaragoza (orcid)0000-0002-4546-4111 Caleiras, Eduardo Notario, Laura Hornos, Felipe Martin-Duque, Pilar De la Vieja, Antonio Santamaria, Jesus Universidad de Zaragoza (orcid)0000-0002-8701-9745 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 2012 755 Universidad de Zaragoza Dpto. Química Física Área Química Física 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente (2026), e00051 [24 pp.] Adv. funct. mater. Advanced Functional Materials 1616-301X 5533584 http://zaguan.unizar.es/record/170449/files/texto_completo.pdf Versión publicada 2487965 http://zaguan.unizar.es/record/170449/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170449 articulos driver 2026-04-18-10:49:47 ARTICLE