000170454 001__ 170454
000170454 005__ 20260420103355.0
000170454 0247_ $$2doi$$a10.1016/j.arr.2026.103109
000170454 0248_ $$2sideral$$a148877
000170454 037__ $$aART-2026-148877
000170454 041__ $$aeng
000170454 100__ $$aBriganti, Stefania
000170454 245__ $$aModeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging
000170454 260__ $$c2026
000170454 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170454 5203_ $$aWith age, human skin undergoes a progressive decline in essential functions, including barrier protection, immunity, and wound healing capacity, which underlie many age-related skin diseases. Skin aging is not only driven by chronological aging, but also strongly influenced by extrinsic stressors, notably ultraviolet radiation, pollutants, and diet. Thus, understanding the complex interplay between these intrinsic and extrinsic factors is essential for developing strategies to preserve skin health across the lifespan. Given the growing appreciation for the physiologic differences between humans and animal models, more advanced in vitro and ex vivo models are needed to dissect the human-specific mechanisms of skin aging and test emerging therapies. In this review, we summarize the major hallmarks of human skin aging and provide an overview of current in vitro modeling approaches that capture both intrinsic and environmental aging mechanisms. We highlight recent advances in complex 3D in vitro systems — including full-thickness human skin equivalents, organoids, and microphysiological platforms — and discuss how these emerging models can be leveraged to interrogate aging biology and support translational research. Together, these developments pave the way for more predictive and mechanistically informed tools to study skin aging and to accelerate the development of next-generation therapeutic and preventive strategies.
000170454 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170454 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170454 700__ $$aCamera, Emanuela
000170454 700__ $$0(orcid)0000-0002-8666-622X$$aCiriza, Jesús$$uUniversidad de Zaragoza
000170454 700__ $$aFernandez-Carro, Estibaliz
000170454 700__ $$aJovanovic Krivokuca, Milica
000170454 700__ $$aLamartine, Jérôme
000170454 700__ $$aLetsiou, Sophia
000170454 700__ $$aNacka-Aleksic, Mirjana
000170454 700__ $$aNiessen, Carien M.
000170454 700__ $$aOliva, Nuria
000170454 700__ $$aPirkovic, Andrea
000170454 700__ $$aSchosserer, Markus
000170454 700__ $$aTobin, Desmond J.
000170454 700__ $$aCavinato, Maria
000170454 700__ $$aConnelly, John T.
000170454 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000170454 773__ $$g118 (2026), 103109 [18 pp.]$$pAGEING RES REV$$tAgeing Research Reviews$$x1568-1637
000170454 8564_ $$s2340142$$uhttps://zaguan.unizar.es/record/170454/files/texto_completo.pdf$$yVersión publicada
000170454 8564_ $$s2224734$$uhttps://zaguan.unizar.es/record/170454/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170454 909CO $$ooai:zaguan.unizar.es:170454$$particulos$$pdriver
000170454 951__ $$a2026-04-18-10:49:52
000170454 980__ $$aARTICLE