170454 20260420103355.0 doi 10.1016/j.arr.2026.103109 sideral 148877 ART-2026-148877 eng Briganti, Stefania Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging 2026 With age, human skin undergoes a progressive decline in essential functions, including barrier protection, immunity, and wound healing capacity, which underlie many age-related skin diseases. Skin aging is not only driven by chronological aging, but also strongly influenced by extrinsic stressors, notably ultraviolet radiation, pollutants, and diet. Thus, understanding the complex interplay between these intrinsic and extrinsic factors is essential for developing strategies to preserve skin health across the lifespan. Given the growing appreciation for the physiologic differences between humans and animal models, more advanced in vitro and ex vivo models are needed to dissect the human-specific mechanisms of skin aging and test emerging therapies. In this review, we summarize the major hallmarks of human skin aging and provide an overview of current in vitro modeling approaches that capture both intrinsic and environmental aging mechanisms. We highlight recent advances in complex 3D in vitro systems — including full-thickness human skin equivalents, organoids, and microphysiological platforms — and discuss how these emerging models can be leveraged to interrogate aging biology and support translational research. Together, these developments pave the way for more predictive and mechanistically informed tools to study skin aging and to accelerate the development of next-generation therapeutic and preventive strategies. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Camera, Emanuela Ciriza, Jesús Universidad de Zaragoza (orcid)0000-0002-8666-622X Fernandez-Carro, Estibaliz Jovanovic Krivokuca, Milica Lamartine, Jérôme Letsiou, Sophia Nacka-Aleksic, Mirjana Niessen, Carien M. Oliva, Nuria Pirkovic, Andrea Schosserer, Markus Tobin, Desmond J. Cavinato, Maria Connelly, John T. 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 118 (2026), 103109 [18 pp.] AGEING RES REV Ageing Research Reviews 1568-1637 2340142 http://zaguan.unizar.es/record/170454/files/texto_completo.pdf Versión publicada 2224734 http://zaguan.unizar.es/record/170454/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170454 articulos driver 2026-04-18-10:49:52 ARTICLE