000170463 001__ 170463
000170463 005__ 20260422085545.0
000170463 0247_ $$2doi$$a10.3390/antibiotics15030321
000170463 0248_ $$2sideral$$a148979
000170463 037__ $$aART-2026-148979
000170463 041__ $$aeng
000170463 100__ $$0(orcid)0000-0001-9771-4912$$aEzquerra-Aznárez, José Manuel$$uUniversidad de Zaragoza
000170463 245__ $$aNew Chemical Scaffold with Antimicrobial Activity Identified in a Screening of Industrial Photoactive Compounds
000170463 260__ $$c2026
000170463 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170463 5203_ $$aBackground/Objectives: The emergence of antimicrobial resistance threatens advances achieved by medicine in the last century. This situation has been exacerbated by the suboptimal outcome of screening campaigns to provide novel antimicrobials. Methods: An alternative strategy was employed to identify new chemical scaffolds with antimicrobial activity. A collection of photoactive compounds originally synthesized for industrial purposes was screened for antibacterial activity. Results: 4H-pyran-4-ylidenes were identified as active against Gram-positive bacteria. Compounds belonging to this family displayed dose-dependent bactericidal activity against both wild-type and methicillin-resistant Staphylococcus aureus. No cytotoxicity was observed in the HepG2 hepatic cell line at the concentrations required for antimicrobial activity against S. aureus. Resistance to 4H-pyran-4-ylidenes in S. aureus was associated with point mutations in the rny locus, which encodes for a ribonuclease that plays a key role in RNA homeostasis. Conclusions: These findings indicate that chemical libraries not originally intended for drug discovery can be an innovative source of chemical diversity for the development of novel antimicrobials.
000170463 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E47-23R$$9info:eu-repo/grantAgreement/ES/UZ/UZ2023-CIE-01
000170463 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170463 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170463 700__ $$aAlonso-Román, Raquel
000170463 700__ $$0(orcid)0000-0002-0111-4697$$aLucía, Ainhoa$$uUniversidad de Zaragoza
000170463 700__ $$0(orcid)0000-0002-3206-9868$$aAndreu, Raquel$$uUniversidad de Zaragoza
000170463 700__ $$0(orcid)0000-0001-9747-1789$$aFranco, Santiago$$uUniversidad de Zaragoza
000170463 700__ $$0(orcid)0000-0003-2076-844X$$aAínsa, José A.$$uUniversidad de Zaragoza
000170463 700__ $$0(orcid)0000-0002-8480-0325$$aRamón-García, Santiago
000170463 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000170463 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000170463 773__ $$g15, 3 (2026), 321 [17 pp.]$$pAntibiotics$$tAntibiotics$$x2079-6382
000170463 8564_ $$s1373292$$uhttps://zaguan.unizar.es/record/170463/files/texto_completo.pdf$$yVersión publicada
000170463 8564_ $$s2340306$$uhttps://zaguan.unizar.es/record/170463/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170463 909CO $$ooai:zaguan.unizar.es:170463$$particulos$$pdriver
000170463 951__ $$a2026-04-22-08:32:56
000170463 980__ $$aARTICLE