000170472 001__ 170472 000170472 005__ 20260422085545.0 000170472 0247_ $$2doi$$a10.1016/j.neurom.2026.03.005 000170472 0248_ $$2sideral$$a148908 000170472 037__ $$aART-2026-148908 000170472 041__ $$aeng 000170472 100__ $$aBarbosa da Silva, Hugo Miguel 000170472 245__ $$aComparison of two ultrasound-guided percutaneous neuromodulation protocols applied to the median nerve on maximal handgrip strength in healthy adults: a randomized clinical trial 000170472 260__ $$c2026 000170472 5060_ $$aAccess copy available to the general public$$fUnrestricted 000170472 5203_ $$aBackground: Ultrasound (US)-guided percutaneous neuromodulation (PNM) has shown promising effects in the neuromuscular field, although its effects in healthy individuals remain unclear. Objective: This study aimed to compare the immediate effects of two different US-guided PNM protocols applied to the median nerve on maximal handgrip strength and pain intensity during intervention in healthy adults. Materials and Methods: A randomized clinical trial was conducted with evaluator and participant blinding, in which 86 healthy adults were assigned to two groups: protocol 1 (10 Hz, 250 μs, 10 seconds of stimulation followed by 10 seconds of rest) and protocol 2 (100 Hz, 350 μs, 5 seconds of stimulation followed by 55 seconds of rest), each receiving one isolated US-guided PNM session of the median nerve at an individualized, nonpainful, and well-tolerated intensity sufficient to elicit a visible muscle contraction. Maximal handgrip strength was assessed before and after the intervention using dynamometry. Pain intensity during intervention was measured using the Numerical Pain Rating Scale. Results: No statistically significant changes were observed in maximal handgrip strength within groups or between groups. Regarding pain perceived by the participants during the PNM intervention, there were no statistically significant differences between the two groups. Conclusions: A single session of US-guided PNM did not produce immediate significant improvements in maximal handgrip strength in healthy adults. No significant differences were found between the protocols studied, or in pain perception between groups during the application of the technique, which was safe and well-tolerated. 000170472 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttps://creativecommons.org/licenses/by-nc/4.0/deed.es 000170472 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000170472 700__ $$aValera-Garrido, Fermín 000170472 700__ $$aMinaya-Muñoz, Francisco 000170472 700__ $$aÁlvarez-Prats, David 000170472 700__ $$0(orcid)0000-0002-6506-6081$$aLapuente-Hernández, Diego$$uUniversidad de Zaragoza 000170472 700__ $$0(orcid)0000-0002-9201-0120$$aHerrero, Pablo$$uUniversidad de Zaragoza 000170472 700__ $$0(orcid)0009-0003-8000-7084$$aCarcasona-Otal, Alberto 000170472 700__ $$aCarvajal-Fernández, Óscar 000170472 7102_ $$11006$$2413$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Fisioterapia 000170472 773__ $$g(2026), 1-9$$pNeuromodulation$$tNEUROMODULATION$$x1094-7159 000170472 8564_ $$s5227368$$uhttps://zaguan.unizar.es/record/170472/files/texto_completo.pdf$$yVersión publicada 000170472 8564_ $$s2278219$$uhttps://zaguan.unizar.es/record/170472/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000170472 909CO $$ooai:zaguan.unizar.es:170472$$particulos$$pdriver 000170472 951__ $$a2026-04-22-08:33:08 000170472 980__ $$aARTICLE