000170931 001__ 170931
000170931 005__ 20260430151735.0
000170931 0247_ $$2doi$$a10.1016/j.mad.2026.112183
000170931 0248_ $$2sideral$$a149024
000170931 037__ $$aART-2026-149024
000170931 041__ $$aeng
000170931 100__ $$0(orcid)0009-0001-5448-5213$$aCastillo-Bernad, Sergio$$uUniversidad de Zaragoza
000170931 245__ $$aEffectiveness of exercise and nutrition interventions for cognitive function in older adults: A systematic review and meta-analysis
000170931 260__ $$c2026
000170931 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170931 5203_ $$aAlthough life expectancy has increased, the proportion of years lived without disability has not improved at the same rate. This has contributed to the rising prevalence of dementia, which currently affects over 55 million people worldwide. In the absence of curative treatments, non-pharmacological strategies such as exercise and diet have attracted interest as a means of preserving cognitive function in older adults. This systematic review and metaanalysis evaluated the effectiveness of combined exercise and dietary or nutritional supplementation interventions on global cognitive function in healthy older adults or those with mild cognitive impairment. Following PRISMA guidelines (PROSPERO ID: CRD42024528600), we searched the following databases up to 1 May 2025: PubMed, Scopus, Web of Science and SportDiscus. Fourteen randomised controlled trials involving 4013 participants aged 65 years or over (mean age: 71.4) without diagnosed dementia were included. Global cognition was assessed using validated tools. The methodological quality was assessed using the PEDro scale and the risk of bias using Cochrane's RoB 2 tool. A random-effects meta-analysis was conducted using the DerSimonian-Laird method, with heterogeneity estimated via the I² statistic. A combined exercise and nutritional intervention significantly improved global cognitive function compared to the control group (SMD: 0.15; 95% CI: 0.07 to 0.24; I²: 50%). A sensitivity analysis that excluded multi-domain interventions confirmed this effect (d = 0.12; 95% CI: 0.02 to 0.22; I² = 0%). However, no significant improvements were found in specific domains, such as executive function or visual-perceptual ability. Variability in methodological protocols, follow-up durations, cognitive tools and adherence measurement limits comparability. While the observed effect size was modest, these findings, in the context of healthy ageing, suggest the potential for these combined interventions to attenuate cognitive decline and preserve functional autonomy, thereby highlighting their role in dementia prevention strategies.
000170931 536__ $$9info:eu-repo/grantAgreement/ES/AEI/RED2022-134800-T$$9info:eu-repo/grantAgreement/ES/ISCIII/CB12-03-30038$$9info:eu-repo/grantAgreement/ES/MCD/EXP 104961$$9info:eu-repo/grantAgreement/ES/MCD/EXP 75079$$9info:eu-repo/grantAgreement/ES/MINECO/DEP2016-78309-R$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/ISCIII-CB16-10-00477$$9info:eu-repo/grantAgreement/ES/UZ/UZCUD2017-BIO-01$$9info:eu-repo/grantAgreement/ES/UZ/UZ2021-BIO-05
000170931 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170931 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170931 700__ $$0(orcid)0000-0003-0330-5558$$aMoradell, Ana$$uUniversidad de Zaragoza
000170931 700__ $$0(orcid)0000-0002-0520-1640$$aGómez-Bruton, Alejandro$$uUniversidad de Zaragoza
000170931 700__ $$0(orcid)0000-0001-8500-1667$$aMatute-Llorente, Ángel$$uUniversidad de Zaragoza
000170931 700__ $$aGonzález-Agüero, Alejandro
000170931 700__ $$0(orcid)0000-0002-7215-6931$$aCasajús, José A.$$uUniversidad de Zaragoza
000170931 700__ $$0(orcid)0000-0001-6492-2512$$aGómez-Cabello, Alba
000170931 700__ $$0(orcid)0000-0002-0137-9900$$aLozano-Berges, Gabriel$$uUniversidad de Zaragoza
000170931 700__ $$0(orcid)0000-0002-4303-4097$$aVicente-Rodríguez, Germán$$uUniversidad de Zaragoza
000170931 7102_ $$12008$$2640$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Nutrición Bromatología
000170931 7102_ $$11006$$2245$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Educación Física y Depor.
000170931 773__ $$g231 (2026), 112183 [17 pp.]$$pMech. ageing dev.$$tMECHANISMS OF AGEING AND DEVELOPMENT$$x0047-6374
000170931 8564_ $$s3248353$$uhttps://zaguan.unizar.es/record/170931/files/texto_completo.pdf$$yVersión publicada
000170931 8564_ $$s2429785$$uhttps://zaguan.unizar.es/record/170931/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170931 909CO $$ooai:zaguan.unizar.es:170931$$particulos$$pdriver
000170931 951__ $$a2026-04-30-13:57:20
000170931 980__ $$aARTICLE