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000170957 005__ 20260430151736.0
000170957 0247_ $$2doi$$a10.5152/eurasianjmed.2026.251290
000170957 0248_ $$2sideral$$a149017
000170957 037__ $$aART-2026-149017
000170957 041__ $$aeng
000170957 100__ $$aFandos Vázquez, Pilar
000170957 245__ $$aHigh Prevalence of Non-thyroidal Illness Syndrome in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis
000170957 260__ $$c2026
000170957 5060_ $$aAccess copy available to the general public$$fUnrestricted
000170957 5203_ $$aOur aim was to estimate the prevalence of non-thyroidal illness syndrome in individuals with chronic obstructive pulmonary disease (COPD). A systematic review and meta-analysis of studies indexed in Embase, ScienceDirect, PubMed, Virtual Health Library, Web of Science, and Cochrane Library from inception through December 31, 2023, was performed. The protocol was registered in PROSPERO (CRD42024492108). Pooled prevalence and 95% CIs were calculated using the DerSimonian–Laird random-effects model, and heterogeneity was assessed with the I2 statistic. Meta-regression analyses examined the influence of age, sex, and smoking status. Subgroup and sensitivity analyses were performed, and associations with arterial blood gas parameters (PaO₂, PaCO₂, and SaO₂) were evaluated using the inverse-variance method within a random-effects framework. Eleven studies including 1005 chronic obstructive pulmonary disease patients met the inclusion criteria. The overall pooled prevalence of non-thyroidal illness syndrome was 44.2% (95% CI, 30.0-58.4%) with high heterogeneity (I2, 96.1%). Non-thyroidal illness syndrome was more common during acute exacerbations (54.5%) than in stable disease (13.8%). Meta-regression analyses showed that age, sex, and smoking status did not significantly account for heterogeneity. Among arterial blood gas parameters, a modest but statistically significant reduction in SaO₂ was observed in patients with non-thyroidal illness syndrome compared with those without (−2.65%, 95% CI, −4.56 to −0.74). No significant differences were detected for PaO₂ or PaCO₂. As a conclusion, non-thyroidal illness syndrome is a common finding in patients with COPD, particularly during acute exacerbations, and is associated with reduced oxygen saturation. These findings highlight the importance of monitoring thyroid function and oxygenation in this population.
Cite this article as: Vázquez PF, Diez-Manglano J. High prevalence of non-thyroidal illness syndrome in patients with chronic obstructive pulmonary disease: A systematic review and metaanalysis. Eurasian J Med. 2026, 58(3), 1290, doi: 10.5152/eurasianjmed.2026.251290
000170957 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000170957 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000170957 700__ $$0(orcid)0000-0002-3132-2171$$aDíez-Manglano, Jesús$$uUniversidad de Zaragoza
000170957 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000170957 773__ $$g58, 3 (2026), 1-6$$tEurasian Journal of Medicine$$x1308-8734
000170957 8564_ $$s1687373$$uhttps://zaguan.unizar.es/record/170957/files/texto_completo.pdf$$yVersión publicada
000170957 8564_ $$s2534985$$uhttps://zaguan.unizar.es/record/170957/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000170957 909CO $$ooai:zaguan.unizar.es:170957$$particulos$$pdriver
000170957 951__ $$a2026-04-30-13:57:52
000170957 980__ $$aARTICLE