170981 20260430151736.0 doi 10.1007/s13555-026-01737-7 sideral 149026 ART-2026-149026 eng Gómez de la Fuente, Enrique Real-World Use of Baricitinib in Patients with Atopic Dermatitis in Spain: DAMA-S Study, A Retrospective Chart Review 2026 Introduction. Baricitinib has shown positive results in clinical trials both from efficacy and safety outcomes; however, there is still a need to further understand its use in routine practice in Spain. Methods. This observational study aimed to describe treatment patterns, persistence, and effectiveness of baricitinib among adult patients with atopic dermatitis (AD) in Spain. A retrospective chart review was carried out in 13 hospitals across Spain. Effectiveness was described using the Eczema Area and Severity Index (EASI), the Investigator’s Global Assessment (IGA), and the Itch and Sleep numerical rating scales (NRS) recorded as part of routine clinical practice. Persistence to treatment was estimated using Kaplan–Meier curves. Results. Seventy-four patients were included and followed for a mean of 42.1 (standard deviation, SD 21.4) weeks. At baseline, over half of the patients had severe AD, with an EASI > 21 (63%) and an IGA-4 (56.8%). Patients had received a mean of 2.4 (SD 1.2) prior systemic treatments and were prescribed baricitinib mainly due to lack of effectiveness of previous treatment. Most patients were prescribed baricitinib as the sole systemic treatment for AD and did not receive any other systemic treatment during the follow-up. During the study period, 39.2% of patients discontinued baricitinib, mainly due to lack of effectiveness. At week 16, 69.7% of patients who remained on treatment and had a measurement available achieved a ≥ 75% improvement from baseline in the EASI (EASI75) response and 79.3% an IGA score of 0 or 1. Conclusions. Among patients who remained on treatment, baricitinib showed meaningful clinical improvements in routine clinical practice in Spain. Our findings highlight rapid and sustained clinical improvements, aligning with that observed in other real-world studies Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Herrera, Enrique Martinez-Espronceda Esquerdo, Iñigo Vidal Sarró, David Figueras-Nart, Ignasi Silvestre Salvador, Juan F. Gilaberte, Yolanda Universidad de Zaragoza (orcid)0000-0001-8034-3617 Santos Alarcón, Sergio Serra-Baldrich, Esther Munera Campos, Monica Moro, Rosa M. Díaz-Cerezo, Silvia Moyano, Sebastian Talavera-Rodríguez, Irene Núñez, Mercedes 1007 183 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Área Dermatología Dermatol. ther. Dermatology and therapy 2193-8210 1414767 http://zaguan.unizar.es/record/170981/files/texto_completo.pdf Versión publicada 2011327 http://zaguan.unizar.es/record/170981/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:170981 articulos driver 2026-04-30-13:58:22 ARTICLE