000171003 001__ 171003
000171003 005__ 20260430151736.0
000171003 0247_ $$2doi$$a10.3390/cancers18061019
000171003 0248_ $$2sideral$$a149049
000171003 037__ $$aART-2026-149049
000171003 041__ $$aeng
000171003 100__ $$0(orcid)0000-0001-7874-2803$$aRuiz Peña, Ana Cristina$$uUniversidad de Zaragoza
000171003 245__ $$aHealth-Related Quality of Life in Menopausal Women with Cancer: Results from the CALCAN Study
000171003 260__ $$c2026
000171003 5060_ $$aAccess copy available to the general public$$fUnrestricted
000171003 5203_ $$aBackground: Menopausal symptoms can negatively affect health-related quality of life (HRQoL), especially in women with a history of cancer. This study compared menopause-specific HRQoL in peri- and postmenopausal women with and without cancer and explored differences by cancer type, menopause treatment use, and depression. Methods: We performed a cross-sectional multicenter study using self-reported data from 6833 women enrolled through the Mi Menopausia mobile app between 2021 and 2024. HRQoL was assessed with the Cervantes SF-16 scale. Results: The final sample consisted of 6833 women: no cancer (n = 6482) and cancer (n = 351), further classified as gynecologic (n = 210) and non-gynecologic (n = 141). Cancer history was associated with worse HRQoL in the Sexuality domain (51.2 ± 23.8 vs. 48.3 ± 24.6; p = 0.013), while global HRQoL did not differ significantly between women with and without cancer (30.6 ± 21.7 vs. 32.3 ± 20.7; p = 0.130). Among cancer women, Sexuality scores were worse in non-gynecologic versus gynecologic cancers (55.7 ± 22.9 vs. 48.2 ± 24.1; p = 0.005). Depression was consistently associated with worse HRQoL in all groups, while menopause treatment use was associated with poorer HRQoL only in women without cancer. Conclusions: Cancer history was mainly associated with poorer sexual menopause-related HRQoL rather than global HRQoL. Depression was a major factor linked to impaired HRQoL, highlighting the need for integrated sexual and mental health assessment in menopausal women, particularly cancer survivors.
000171003 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000171003 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000171003 700__ $$aBaquedano Mainar, Laura$$uUniversidad de Zaragoza
000171003 700__ $$aCoronado Martín, Pluvio J.
000171003 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000171003 773__ $$g18, 6 (2026), 1019$$pCancers$$tCancers$$x2072-6694
000171003 8564_ $$s327841$$uhttps://zaguan.unizar.es/record/171003/files/texto_completo.pdf$$yVersión publicada
000171003 8564_ $$s2248952$$uhttps://zaguan.unizar.es/record/171003/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000171003 909CO $$ooai:zaguan.unizar.es:171003$$particulos$$pdriver
000171003 951__ $$a2026-04-30-13:58:49
000171003 980__ $$aARTICLE