171003 20260430151736.0 doi 10.3390/cancers18061019 sideral 149049 ART-2026-149049 eng Ruiz Peña, Ana Cristina Universidad de Zaragoza (orcid)0000-0001-7874-2803 Health-Related Quality of Life in Menopausal Women with Cancer: Results from the CALCAN Study 2026 Background: Menopausal symptoms can negatively affect health-related quality of life (HRQoL), especially in women with a history of cancer. This study compared menopause-specific HRQoL in peri- and postmenopausal women with and without cancer and explored differences by cancer type, menopause treatment use, and depression. Methods: We performed a cross-sectional multicenter study using self-reported data from 6833 women enrolled through the Mi Menopausia mobile app between 2021 and 2024. HRQoL was assessed with the Cervantes SF-16 scale. Results: The final sample consisted of 6833 women: no cancer (n = 6482) and cancer (n = 351), further classified as gynecologic (n = 210) and non-gynecologic (n = 141). Cancer history was associated with worse HRQoL in the Sexuality domain (51.2 ± 23.8 vs. 48.3 ± 24.6; p = 0.013), while global HRQoL did not differ significantly between women with and without cancer (30.6 ± 21.7 vs. 32.3 ± 20.7; p = 0.130). Among cancer women, Sexuality scores were worse in non-gynecologic versus gynecologic cancers (55.7 ± 22.9 vs. 48.2 ± 24.1; p = 0.005). Depression was consistently associated with worse HRQoL in all groups, while menopause treatment use was associated with poorer HRQoL only in women without cancer. Conclusions: Cancer history was mainly associated with poorer sexual menopause-related HRQoL rather than global HRQoL. Depression was a major factor linked to impaired HRQoL, highlighting the need for integrated sexual and mental health assessment in menopausal women, particularly cancer survivors. Access copy available to the general public Unrestricted info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Baquedano Mainar, Laura Universidad de Zaragoza Coronado Martín, Pluvio J. 1013 645 Universidad de Zaragoza Dpto. Cirugía Área Obstetricia y Ginecología 18, 6 (2026), 1019 Cancers Cancers 2072-6694 327841 http://zaguan.unizar.es/record/171003/files/texto_completo.pdf Versión publicada 2248952 http://zaguan.unizar.es/record/171003/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:171003 articulos driver 2026-04-30-13:58:49 ARTICLE